| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:D-threo-PPMP hydrochloride
CAS:139889-65-9
Purity:98% Package:1G;10G;100G Remarks:D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor, which is the active enantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP. In MDCK kidney epithelial cells, D-thr
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:D-threo-PPMP hydrochloride
CAS:139889-65-9
Package:5mg/RMB 3670;10mg/RMB 6930
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:D-threo-PPMP (hydrochloride)
CAS:139889-65-9
Purity:98% Package:5mg;10mg
|
| Company Name: |
SHANGHAI ZZBIO CO., LTD.
|
| Tel: |
15102117276 19921389125 |
| Email: |
tech@zzbioco.com |
| Products Intro: |
Product Name:D-threo-PPMP
CAS:139889-65-9
Purity:98+% Package:10mg
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D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL manufacturers
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| | D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Basic information |
| Product Name: | D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL | | Synonyms: | D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL;D-THREO-PPMP;D-threo-PPMP (hydrochloride);D threo PPMP hydrochloride,DthreoPPMP hydrochloride;R-(R*,R*)]-N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-hexadecanamide,monohydrochloride;D-threo-PPMP (PPMP), glucosylceramide synthase inhibitor | | CAS: | 139889-65-9 | | MF: | C29H51ClN2O3 | | MW: | 511.19 | | EINECS: | | | Product Categories: | | | Mol File: | 139889-65-9.mol |  |
| | D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Ethanol: Soluble,Methanol: Soluble | | form | A solid | | color | White to off-white |
| | D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Usage And Synthesis |
| Description | D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor., It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growth in vitro at 20 μM and significantly inhibits DNA synthesis at 3 μM. [Matreya, LLC. Catalog No. 1865] | | Uses | D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production[1][2]. | | References | [1] Gouazé V, et, al. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005 May 1;65(9):3861-7. DOI:10.1158/0008-5472.CAN-04-2329
[2] Hernandez Y. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul;76(7):2939-49. DOI:10.1128/IAI.00116-08
[3] Wu X, et, al. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):44-8. DOI:10.1016/j.jchromb.2006.03.060 |
| | D-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Preparation Products And Raw materials |
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