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Product Name:Dimethyl-W84 dibromide
CAS:402475-33-6
Purity:98% Package:1G;10G;100G Remarks:Dimethyl-W84 is a selective allosteric modulator of the M2 muscarinic acetylcholine receptor. It hinders the dissociation of the orthosteric antagonist N-methylscopolamine from the M2 receptor.
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DIMETHYL-W84 DIBROMIDE manufacturers
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| | DIMETHYL-W84 DIBROMIDE Basic information |
| Product Name: | DIMETHYL-W84 DIBROMIDE | | Synonyms: | DIMETHYL-W84 DIBROMIDE;6-[dimethyl-[3-(5-methyl-1,3-dioxoisoindol-2-yl)propyl]azaniumyl]hexyl-dimethyl-[3-(5-methyl-1,3-dioxoisoindol-2-yl)propyl]azanium;DimethylW84 (dibromide),Dimethyl W84 (dibromide),Dimethyl-W-84 (dibromide);Dimethyl-W84 dibromide, M2-receptor selective modulator | | CAS: | 402475-33-6 | | MF: | C34H48BrN4O4+ | | MW: | 656.69 | | EINECS: | | | Product Categories: | | | Mol File: | 402475-33-6.mol |  |
| | DIMETHYL-W84 DIBROMIDE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: soluble; Water: soluble | | form | White to off-white solid. |
| | DIMETHYL-W84 DIBROMIDE Usage And Synthesis |
| Description | Dimethyl-W84 is a selective allosteric modulator of the M2 muscarinic acetylcholine receptor. It hinders the dissociation of the orthosteric antagonist N-methylscopolamine from the M2 receptor with an EC50 value of 3 nM. | | Uses | Dimethyl-W84 dibromide is a potent allosteric modulator of muscarinic receptors also selective for M2-receptors. | | References | [1] C TR?NKLE. Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors.[J]. Molecular Pharmacology, 1998, 54 1: 139-145. DOI: 10.1124/mol.54.1.139
[2] CHRISTIAN TR?NKLE. Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.[J]. Molecular Pharmacology, 2003, 64 1: 180-190. DOI: 10.1124/mol.64.1.180 |
| | DIMETHYL-W84 DIBROMIDE Preparation Products And Raw materials |
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