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| | 1,3-Cyclohexanedione, 5-[(1S)-1-[3,5-bis(trifluoromethyl)phenoxy]ethyl]- Basic information |
| | 1,3-Cyclohexanedione, 5-[(1S)-1-[3,5-bis(trifluoromethyl)phenoxy]ethyl]- Chemical Properties |
| Boiling point | 382.4±42.0 °C(Predicted) | | density | 1.361±0.06 g/cm3(Predicted) | | form | Solid | | pka | 4.89±0.20(Predicted) | | color | White to light yellow |
| | 1,3-Cyclohexanedione, 5-[(1S)-1-[3,5-bis(trifluoromethyl)phenoxy]ethyl]- Usage And Synthesis |
| Uses | AKV-9 is the inhibitor for mutated Cu/Zn superoxide dismutase (SOD1), that inhibits SOD1-induced protein aggregation and exhibits protective efficacy against SOD1-induced cytotoxicity in PC-12 with an EC50 of 0.3 μM. AKV-9 ameliorates amyotrophic lateral sclerosis in mouse models and extends their lifespan[1]. | | References | [1] Zhang Y, et al., Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS. ACS Med Chem Lett. 2012 May 22;3(7):584-587. DOI:10.1021/ml3000963 |
| | 1,3-Cyclohexanedione, 5-[(1S)-1-[3,5-bis(trifluoromethyl)phenoxy]ethyl]- Preparation Products And Raw materials |
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