1H,1H,7H-DODECAFLUORO-1-HEPTANOL NEW

Price	$6	$5	$1
Package	1KG	25KG	100KG

Min. Order:	1KG
Supply Ability:	g-kg-tons, free sample is available
Update Time:	2024-03-29

Product Details

Product Name: 1H,1H,7H-DODECAFLUORO-1-HEPTANOL	CAS No.: 335-99-9
Min. Order: 1KG	Purity: 99%
Supply Ability: g-kg-tons, free sample is available	Release date: 2024/03/29
Lead time: In stock	Packaging: bottle/drum/bucket/IBC, as request.
Delivery: By sea, by air, by express	Origin: Manufacturer
Name: Sun

1. Product information

Name	[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid
Synonym	More Synonyms

Description	Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 of 3.4 nM (Ki of 0.93 nM).
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Cancer
Target	IC50: 3.4 nM (20S proteasome)[1] Ki: 0.93 nM (20S proteasome)[1]
In Vitro	Ixazomib (MLN2238) is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 value of 3.4 nM (Ki of 0.93 nM). At higher concentrations, Ixazomib (MLN2238) also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites (IC50 of 31 and 3,500 nM, respectively). Cell viability studies are performed in a variety of mammalian cell lines to compare the in vitro antiproliferative effects of Ixazomib (MLN2238) with Bortezomib. Studies performed with A375 (lung), H460 (lung), HCT-116 (colon), and HT-29 (colon) cells revealed similar LD50 values for the two compounds, which range from 4 to 58 nM[1].
In Vivo	Ixazomib (MLN2238) shows antitumor activity in the CWR22 xenograft model. The antitumor effects of Ixazomib (MLN2238) dosed at 14 mg/kg i.v. or 7 mg/kg i.v. are compared with Bortezomib dosed at 0.8 mg/kg i.v. or 0.4 mg/kg i.v. on a twice weekly regimen. The high dose for both Ixazomib (MLN2238) and Bortezomib shows similar antitumor activity in this model (T/C=0.36 and 0.44, respectively). However, Ixazomib (MLN2238) (7 mg/kg) shows greater efficacy at a 0.5 MTD dose compared with a 0.5 MTD dose of Bortezomib (0.4 mg/kg; T/C=0.49 compared with T/C=0.79, respectively) Ixazomib (MLN2238) shows time-dependent reversible proteasome inhibition; however, the proteasome dissociation half-life (t1/2) for Ixazomib (MLN2238) is determined to be 18 minutes[1].
Cell Assay	Calu-6 cells are cultured in MEM containing 10% fetal bovine serum and 1% penicillin/streptomycin and plated 1 d before the start of the experiment at 10,000 cells per well in a 384-well plate. For IC50 determinations, cells are treated with varying concentrations of Bortezomib or Ixazomib in DMSO (0.5% final, v/v) for 1 h at 37°C. For reversibility experiments, cells are treated with either 1 μM Bortezomib or Ixazomib (MLN2238) for 30 min at 37°C and then washed thrice in medium to remove the compounds. Cells are incubated for an additional 4 h at 37°C, after which the medium is removed and replaced with fresh medium. Proteasome activity is assessed by monitoring hydrolysis of the chymotrypsin-like substrate Suc-LLVY-aminoluciferin in the presence of luciferase using the Proteasome-Glo assay reagents. Luminescence is measured using a LEADseeker instrument[1].
Animal Admin	Mice[1] Male CB17-SCID mice, approximately 8 to 11 wk of age, are inoculated s.c. with freshly dissected CWR22 tumor fragments (~20 mg) in the right dorsal flank. Mean tumor volume (MTV) is calculated using the following formula: 0.5×(length×width2). When MTV reaches approximately 150 to 200 mm3, animals are randomized into treatment groups (n=10 per group) before dosing. Antitumor activity is determined at the end of the study by calculating the treatment over control (T/C) ratio of their MTVs at the end of the study. Rats[1] To determine the pharmacokinetic profile of Ixazomib and Bortezomib in a second species, Sprague-Dawley rats are administered a single i.v. dose of Ixazomib (MLN2238) at either 0.3 or 0.2 mg/kg or Bortezomib at 0.2 mg/kg. Both Ixazomib doses provided a greater plasma exposure (AUC0-48h of 704 and 1,070 h•ng/mL for 0.2 and 0.3 mg/kg doses, respectively) compared with Bortezomib (AUC0-48h of 206 h•ng/mL), confirming that Ixazomib (MLN2238) also has improved plasma exposure compared with Bortezomib in rodents.
References	[1]. Kupperman E, et al. Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res. 2010 Mar 1;70(5):1970-80.

Density	1.3±0.1 g/cm3
Molecular Formula	C₁₄H₁₉BCl₂N₂O₄
Molecular Weight	361.029
Exact Mass	360.081482
PSA	105.64000
LogP	2.82
Index of Refraction	1.546
Storage condition	2-8°C

Name	2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol
Synonym	More Synonyms

Density	1.6±0.1 g/cm3
Boiling Point	163.3±40.0 °C at 760 mmHg
Melting Point	-20°C
Molecular Formula	C₇H₄F₁₂O
Molecular Weight	332.087
Flash Point	52.5±27.3 °C
Exact Mass	332.007050
PSA	20.23000
LogP	3.58
Vapour Pressure	0.7±0.7 mmHg at 25°C
Index of Refraction	1.291

MSDS(Chinese)

Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S37/39-S26
RTECS	MJ4500000
HS Code	2905590090

trimethyl-(1H,1...

CAS#:56002-71-2

2,2,3,3,4,4,5,5...

CAS#:335-99-9

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 17, p. 1699 - 1703 Zhurnal Organicheskoi Khimii, , vol. 17, p. 1903 - 1908

Methanol

CAS#:67-56-1

Tetrafluoroethylene

CAS#:116-14-3

2,2,3,3,4,4,5,5...

CAS#:335-99-9

Literature: Industrial and Engineering Chemistry, , vol. 51, p. 829

bis(2,2,3,3,4,4...

CAS#:85892-57-5

~86%

Benzenesulfonamide

CAS#:98-10-2

2,2,3,3,4,4,5,5...

CAS#:335-99-9

Literature: Markovskii, L. N.; Stukalo, E. A.; Ogloblin, A. N.; Iksanova, S. V. Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 1 p. 65 - 70 Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 1 p. 72 - 79

Precursor 7	Previous 1/2 Next
CAS#:78491-64-2 tetrakis((2,2,3... CAS#:56002-71-2 trimethyl-(1H,1... CAS#:67-56-1 Methanol CAS#:116-14-3 Tetrafluoroethylene
DownStream 9	Previous 1/3 Next
CAS#:3830-74-8 2,2,4,4,6-penta... CAS#:19493-30-2 1H,7H-PERFLUORO... CAS#:28393-02-4 10,12-DOCOSADIY... CAS#:2355-57-9 bis(1h,1h,7h-pe...

HS Code	2905590090
Summary	2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

1H,1H,7H-Dodecafluoro-1-heptanol

2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol

MFCD00039630

1,1,7-Trihydrododecafluoroheptan-1-ol

EINECS 206-406-6

2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptanol

1,1,7-Trihydroperfluoroheptanol

1h,1h,7h-dodecafluoroheptanol

1H,1H,7H-Perfluoroheptan-1-ol

7,7,6,6,5,5,4,4,3,3,2,2-Dodecafluoroheptanol

2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-1-heptanol

1-Heptanol,2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro

1-Heptanol, 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-

1,1,7-Trihydrododecafluoroheptanol

2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

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3. Shipping

Article illustration

4. Contact information

For more details, pls contact us freely.

Email address : Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137

Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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