N-Boc-trans-4-Hydroxy-L-proline methyl ester NEW

Price	$6	$5	$1
Package	1KG	25KG	100KG

Min. Order:	1KG
Supply Ability:	g-kg-tons, free sample is available
Update Time:	2024-03-29

Product Details

Product Name: N-Boc-trans-4-Hydroxy-L-proline methyl ester	CAS No.: 74844-91-0
Min. Order: 1KG	Purity: 99%
Supply Ability: g-kg-tons, free sample is available	Release date: 2024/03/29
Lead time: In stock	Packaging: bottle/drum/bucket/IBC, as request.
Delivery: By sea, by air, by express	Origin: Manufacturer
Name: Sun

1. Product information

Name	N-Boc-trans-4-Hydroxy-L-proline methyl ester
Synonym	More Synonyms

Description	Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.2±0.1 g/cm3
Boiling Point	335.2±42.0 °C at 760 mmHg
Melting Point	92-96 °C(lit.)
Molecular Formula	C₁₁H₁₉NO₅
Molecular Weight	245.272
Flash Point	156.6±27.9 °C
Exact Mass	245.126328
PSA	76.07000
LogP	-0.25
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.501
Storage condition	2~8°C

Boc-Hyp-OMe MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

Di-tert-butyl d...

24424-99-5

H-Hyp-OMe hydro...

40216-83-9

~99%

Boc-Hyp-OMe

74844-91-0

Literature: Grygorenko, Oleksandr O.; Komarov, Igor V.; Cativiela, Carlos Tetrahedron Asymmetry, 2009 , vol. 20, # 12 p. 1433 - 1436

Boc-Hyp-OH

13726-69-7

methyl iodide

74-88-4

~96%

Boc-Hyp-OMe

74844-91-0

Literature: LG LIFE SCIENCE LTD. Patent: US2010/120783 A1, 2010 ; Location in patent: Page/Page column 10 ; US 20100120783 A1

Di-tert-butyl d...

24424-99-5

(2S,4R)-METHYL ...

1499-56-5

~97%

Boc-Hyp-OMe

74844-91-0

Literature: Tanaka, Fujie; Barbas, Carlos F.; Zhang, Haile Patent: US2007/117986 A1, 2007 ; Location in patent: Page/Page column 21; 22 ;

Precursor 9	Previous 1/3 Next
CAS#:24424-99-5 Di-tert-butyl d... CAS#:40216-83-9 H-Hyp-OMe hydro... CAS#:13726-69-7 Boc-Hyp-OH CAS#:74-88-4 methyl iodide
DownStream 10	Previous 1/3 Next
CAS#:336818-78-1 (2S,4R)-Boc-4-P... CAS#:487048-28-2 n-boc-cis-4-cya... CAS#:317357-42-9 3-FLUORO-4-FORM... CAS#:51-35-4 L-Hydroxyproline

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester

N-BOC-transydro-L-prolinemethylester

1-O-tert-butyl 2-O-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate

N-BOC-4-HYDROXY-L-PROLINE METHYL ESTER

N-BOC-L-Hydroxyproline methyl ester

1-tert-Butyl 2-Methyl (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylate

BOC-HYDROXYPROLINE-OME

N-(tert-Butoxycarbonyl)-cis-4-hydroxy-L-proline Methyl Ester

BOC-L-4-HYDROXYPROLINE METHYL ESTER

N-Boc-trans-hydro-L-prolinemethylester

N-Boc-cis-4-Hydroxy-L-prolinem ethylester

N-Boc-trans-4-Hydroxy-L-prolinemethylester

Boc-Hyp-Ome

(2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

MFCD00076981

BOC-L-HYDROXYPROLINE METHYL ESTER

BOC-L-T-4-HYDROXYPROLINE METHYL ESTER

Boc-trans-4-hydroxy-L-proline methyl ester

N-Boc-cis-4-hydroxy-L-proline methyl ester

Boc-cis-Hyp-OMe

cis-Boc-Hyp-OMe

2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

Article illustration

3. Shipping

Article illustration

4. Contact information

For more details, pls contact us freely.

Email address : Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137

Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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