1-Hydroxybenzotriazole NEW
| Price | Get Latest Price |
| Package | 25KG |
| Min. Order: | 1KG |
| Supply Ability: | 50000KG/month |
| Update Time: | 2023-08-29 |
Product Details
| Product Name: 1-Hydroxybenzotriazole | CAS No.: 2592-95-2 |
| EC-No.: 219-989-7 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: 50000KG/month |
| Release date: 2023/08/29 |
| CAS: | 2592-95-2 |
| MF: | C6H5N3O |
| MW: | 135.12 |
| EINECS: | 219-989-7 |
| Product Categories: | 1;Peptide coupling agents;Amino Acid Derivatives;FINE Chemical & INTERMEDIATES;Peptide Coupling Reagents;Peptide;Fused Ring Systems;peptides |
| Mol File: | 2592-95-2.mol |
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| 1-Hydroxybenzotriazole Chemical Properties |
| Melting point | 156-159°C |
| Boiling point | 149-150 °C |
| density | 1 g/cm3 |
| vapor pressure | 0.009Pa at 25℃ |
| refractive index | n20/D 1.488 |
| Fp | 95 °C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 7.39±0.58(Predicted) |
| form | Solid |
| color | White to off-white crystalline powder |
| Water Solubility | 4.201g/L at 29℃ |
| Stability: | Stable, but possible risk of explosion if heated under confinement. Flammable. |
| LogP | 0.146 at 25℃ |
| CAS DataBase Reference | 2592-95-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-benzotriazole, 1-hydroxy-(2592-95-2) |
| EPA Substance Registry System | 1H-Benzotriazole, 1-hydroxy- (2592-95-2) |
| 1-Hydroxybenzotriazole Usage And Synthesis |
| Chemical Properties | white to light yellow powder |
| Uses | additive for oligonucleotide couplings and in racemization-free peptide couplings |
| Uses | 1-Hydroxybenzotriazole (HOBT) is used in preparation method of carbon fiber/polyamide composite powder material for laser sintering. |
| Definition | ChEBI: 1-Hydroxybenzotriazole is a member of benzotriazoles. |
| Flammability and Explosibility | Notclassified |
| Biological Activity | hydroxy benzotriazole, abbreviated hobt, is anorganic compoundthat is a derivative of benzotriazole. hobt, as a commercial product, is a white crystalline powder contains some water (~11.7% wt as the hobt monohydrate crystal). it is mainly used to suppress the racemization of single-enantiomerchiral molecules and to improve the efficiency ofpeptide synthesis. automated peptide synthesisinvolves the condensation of the amino group of protected amino acidswith the activated ester. hobt can be used to produce activated esters such as n-hydroxysuccinimide ester. these esters are insoluble and react with amines at ambient temperature to give amides [1]. hobt is also used for the synthesis of amides from carboxylic acidsaside from amino acids. these substrates may not be convertible to theacyl chlorides [2]. for instance amide derivatives of ionophoric antibiotics have been prepared in this way [3]. |
| target | racemization |
| Purification Methods | Crystallise HOBt from aqueous EtOH or water. [Boyle & Jones J Chem Soc Perkin Trans II 160 1973, Tomita & Ikawa J Pharm Soc Jpn 75 449 1955, Beilstein 26 III/IV 95.] |
| references | [1]. knig w, geiger r. eineneuemethodezursynthese von peptiden: aktivierung der carboxylgruppemitdicyclohexylcarbodiimidunterzusatz von 1‐hydroxy‐benzotriazolen[j]. chemischeberichte, 1970, 103(3): 788-798. [2]. myers a g, yang b h, chen h. transformation of pseudoephedrine amides into highly enantiomerically enriched aldehydes, alcohols, and ketones[j]. organic syntheses, 2000: 29-29. [3]. owicki d, huczyński a, ratajczak-sitarz m, et al. structural and antimicrobial studies of a new n-phenylamide of monensin a complex with sodium chloride[j]. journal of molecular structure, 2009, 923(1): 53-59. |
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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