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Postion:Product Catalog >API>Circulatory system drugs>Anti-atherosclerotic Drugs>Ezetimibe
Ezetimibe
  • Ezetimibe
  • Ezetimibe
  • Ezetimibe
  • Ezetimibe
  • Ezetimibe

Ezetimibe NEW

Price $220 $180 $120
Package 1Kg/Bag 25Kg/Bag 100Kg/Bag
Min. Order: 1Kg/Bag
Supply Ability: 20 tons
Update Time: 2024-04-22

Product Details

Product Name: Ezetimibe CAS No.: 163222-33-1
EC-No.: 682-606-0 Min. Order: 1Kg/Bag
Purity: 98% up / GMP Supply Ability: 20 tons
Release date: 2024/04/22

Product Information

Product name

Ezetimibe

CAS No.

163222-33-1

Molecular Formula

C24H21F2NO3

Molecular Weight

409.43

Quality Standard

98% up by HPLC, GMP,DMF,CEP

Appearance

White powder


Usage

Function of Ezetimibe

Ezetimibe is ananti-hyperlipidemic drug used for lowering the plasma cholesterol levels. It is indicated as an adjunctive therapy to diet for the reduction of high-level total-C, LDL-C, and ApoB in patients suffering primary (heterozygous familial and non-familial) hypercholesterolemia. It is also used in combination therapy with HMG-CoA reductase inhibitors.Ezetimibe does not inhibit the cholesterol synthesis in the liver, or increase bile acid excretion.Instead, ezetimibe takes effect throughacting at the brush border of the small intestine and inhibiting the absorption of cholesterol, further leading to a decrease in the delivery of intestinal cholesterol to the liver, This causes a reduction of hepatic cholesterol stores and an increase in clearance of blood cholesterol.


COA of Ezetimibe


ITEMS

SPECIFICATION

RESULT

Appearance

White powder

Conforms

Specific rotation

-25.0~ -29.0

-26.2

Melting range

160C ~167C

163C~166C


Identity

Retention time: Similar to Reference Substance

Conforms

IR: Similar to Reference Substance

Conforms

Chloride

 0.01%

Conforms

Loss on drying

 0.5%

0.11%

Sulphated Ash

 0.1%

0.01%

Enantiomer

 0.15%

Undetected

Diastereomer

 0.15%

Undetected

Heavy metals

 10 ppm

Conforms

Related substances

Single impurity  0.10%

Total impurity  1.0%

0.06%

0.2%


  Residual solvents

Methanol  3000ppm

Isopropanol  5000ppm

Chlorobenzene  360ppm

Undetected

351ppm

Undetected

Assay

98.0102.0%(calculated on the dried basis )

99.9%

Conclusion

The results above meet all requirements under Ezetimibe in In-House Standard.

Company Information

Article illustration




Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

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