2-Picolinic acid
| Price | $1.99 |
| Package | 10KG |
| Min. Order: | 1KG |
| Supply Ability: | 400tons |
| Update Time: | 2022-02-25 |
Product Details
| Product Name: 2-Picolinic acid | CAS No.: 98-98-6 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: 400tons | Release date: 2022/02/25 |
| Description | PCL 016 is a topical antiviral agent, which inhibits adenovirus replication in rabbit. |
|---|---|
| Related Catalog | Natural Products >> Others Research Areas >> Infection |
| Target | Human Endogenous Metabolite |
| In Vivo | Topical 1.5% PCL, 0.8% PCL, 0.369% PCL (pH7), 0.369% PCL (pH4) and 0.5% CDV are significantly more effective than the Control in reducing Ad Positive Cultures/Total (Days 1-14) and the Duration of Ad Shedding in the Ad5/NZW rabbit ocular model. Although not statistically significant, there appears to be a trend toward concentration-dependent efficacy of PCL 016 on the Duration of Ad Shedding. There is no apparent ocular toxicity associated with PCL 016 concentrations[1]. |
| Animal Admin | Rabbits[1] 25 NZW rabbits are topically inoculated in both eyes, following corneal scarification, with 1.5 x 106 pfu/eye of Ad5. On day 1, the rabbits are divided into 6 topical treatment groups: I - 1.5% PCL 016 pH 7.0 (n=4); II - 0.8% PCL 016 pH 7.0 (n=4); III - 0.369% PCL 016 pH 7.0 (n=4); IV - 0.369% PCL 016 pH 4.0 (n=4); V - 0.5% Cidofovir (CDV) (n=4); VI - Control (saline) (n=5). PCL 016 and control rabbits are treated in both eyes 4 times daily for 7 days, while CDV rabbits are treated in both eyes twice daily for 7 days. All eyes are cultured for virus on days 0, 1, 3, 4, 5, 7, 9, 11, and 14[1]. |
| References | [1]. E.G. Romanowski, et al. A Novel Topical Antiviral Agent, PCL–016 (Picolinic Acid), Inhibits Adenovirus Replication in the Ad5/NZW Rabbit Ocular Model. ARVO Annual Meeting Abstract. May 2005 Volume 46, Issue 13. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 292.5±13.0 °C at 760 mmHg |
| Melting Point | 139-142 °C(lit.) |
| Molecular Formula | C6H5NO2 |
| Molecular Weight | 123.109 |
| Flash Point | 130.7±19.8 °C |
| Exact Mass | 123.032028 |
| PSA | 50.19000 |
| LogP | -0.10 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.571 |
| Storage condition | Store at RT. |
| Water Solubility | 887 g/L (20 ºC) |
Ulrica JiangTrade member
Hong Kong TianSheng new material trading Co., LTD.
Website：https://www.tianshengjt.com
Whatsapp：+86 17320697058
Email：ulrica@hktiansheng.com
Company Profile Introduction
My name is Nancy, the export manager of Hong Kong Tiansheng New Material Trading Co., LTD. We specialize in the production and export of various chemical materials, pharmaceutical raw materials.
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