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2-Picolinic acid

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Company Name: Anhui Dexinjia Biopharm Co., Ltd
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Products Intro: Product Name:Picolinic acid
Purity:99% Package:25KG;10USD
Company Name: Shanghai UCHEM Inc.
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Purity:0.99 Package:1kg;40USD
Company Name: Hebei Fengqiang Trading Co., LTD
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Products Intro: Product Name:2-Picolinic acid
Purity:99 Package:1bag;100USD
Company Name: Anhui Zhongda Biotechnology Co., Ltd
Tel: +8619956560829
Products Intro: Product Name:2-Picolinic acid
Purity:99% Package:1000g;10USD
Company Name: Frapp's ChemicalNFTZ Co., Ltd.
Tel: +86 (576) 8169-6106
Products Intro: Product Name:Picolinic acid

2-Picolinic acid manufacturers

  • Picolinic acid
  • Picolinic acid pictures
  • $0.00 / 25Kg/Drum
  • 2023-12-06
  • CAS:98-98-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 500mt/year
  • Picolinic acid
  • Picolinic acid pictures
  • $40.00 / 1kg
  • 2023-11-20
  • CAS:98-98-6
  • Min. Order: 1kg
  • Purity: 0.99
  • Supply Ability: 25kg
  • 2-Picolinic acid
  • 2-Picolinic acid pictures
  • $10.00 / 1000g
  • 2023-11-03
  • CAS:98-98-6
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 500tons

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2-Picolinic acid Basic information
Product Name:2-Picolinic acid
Synonyms:Picolinic acid, 99% 25GR;acidepicolique;alpha-Pyridinecarboxylic acid;alpha-pyridinecarboxylicacid;o-Pyridinecarboxylic acid;o-pyridinecarboxylicacid;Pyridinecarboxylic acid-(2);Pyridine-carboxylique-2
Product Categories:Pyridine series;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Organic acids;API intermediates;Pyridine;carboxylic acid;Pyridines;Nitrogen cyclic compounds;C6 to C7;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Intermediate;bc0001;98-98-6
Mol File:98-98-6.mol
2-Picolinic acid Structure
2-Picolinic acid Chemical Properties
Melting point 139-142 °C (lit.)
Boiling point 229.19°C (rough estimate)
density 1.3147 (rough estimate)
vapor pressure 0.028Pa at 25℃
refractive index 1.5423 (estimate)
Fp 139°(232°F)
storage temp. Store below +30°C.
solubility H2O: 50 mg/mL, clear
pka1.07(at 25℃)
form Crystalline Powder
color White to almost white
PH3.1 (50g/l, H2O, 20℃)
Water Solubility 887 g/L (20 ºC)
Merck 14,7403
BRN 109595
CAS DataBase Reference98-98-6(CAS DataBase Reference)
NIST Chemistry Reference2-Pyridinecarboxylic acid(98-98-6)
EPA Substance Registry System2-Pyridinecarboxylic acid (98-98-6)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36-36/37/38
Safety Statements 26-36-33-24/25
WGK Germany 3
RTECS TJ7344000
HS Code 29333999
MSDS Information
2-Pyridinecarboxylic acid English
SigmaAldrich English
ACROS English
ALFA English
2-Picolinic acid Usage And Synthesis
Chemical PropertiesOff-white to tan powder. easily soluble in glacial acetic acid, almost insoluble in ether, chloroform and carbon disulfide.
Uses2-Picolinic acid is used as a chelate for alkaline earth metals. It is also used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.
DefinitionChEBI: Picolinic acid is a pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan. It has a role as a MALDI matrix material and a human metabolite. It is a conjugate acid of a picolinate.
Application2-Picolinic acid is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.
Metal complexes of picolinic acid were prepared by the refluxion of metal salts and picolinic acid in ethanol taking 1:3 molar ratio for 6 hours. The solutions were concentrated and cooled, to crystallize out the complexes.The complexes were washed with ether to remove the excess ligand.
Synthesis2-Picolinic acid synthesis: In a 500ml three-necked flask, add 100g of 2-cyanopyridine and 200g of deionized water, then start stirring, heat up to 50°C, add 128.2g of 30% sodium hydroxide to the flask, after adding, add Continue to heat up, react under reflux for 4 hours, then distill water, after 50 g of distilled water, cool the reaction solution to 20°C, add 30% hydrochloric acid, adjust the pH value of the reaction solution to 2.5, then turn on the steam to heat up the water and steam to the kettle When the temperature reaches 120°C, the reaction solution is evaporated to dryness, and the distilled water is completed. Then, 300 g of anhydrous alcohol is added dropwise to the flask to maintain the temperature of the reaction solution at 55°C. After cooling and crystallization, a solid was precipitated, filtered and dried to obtain 106.0 g of 2-picolinic acid with a yield of 89.6%.
Purification MethodsCrystallise the acid from water or *benzene. The picrate has m 185-187o (from MeOH). [Beilstein 22 H 33, 22 I 502, 22 II 30, 22 III/IV 303, 22/2 V 3.]
Tag:2-Picolinic acid(98-98-6) Related Product Information
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