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Postion:Product Catalog >Biochemical Engineering>Saccharides>Monosaccharide>AICAR
AICAR
  • AICAR
  • AICAR
  • AICAR
  • AICAR
  • AICAR

AICAR

Price $10
Package 1KG
Min. Order: 10G
Supply Ability: 1000kg
Update Time: 2018-10-22

Product Details

Product Name: AICAR CAS No.: 2627-69-2
Min. Order: 10G Purity: 99%
Supply Ability: 1000kg Release date: 2018/10/22
 
AICAR Basic information
adenosine regulating agents
Product Name: AICAR
Synonyms: ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR;Akt;mTOR;PI3K
Mol File: 2627-69-2.mol
Article illustration
 
AICAR Chemical Properties
Melting point  214-215 °C
storage temp.  −20°C
solubility  H2O: >10 mg/mL
form  powder
color  tan
Water Solubility  Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml
λmax 265nm(NaOH)(lit.)
Merck  14,16
InChIKey RTRQQBHATOEIAF-UUOKFMHZSA-N
CAS DataBase Reference 2627-69-2(CAS DataBase Reference)
EPA Substance Registry System 1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2)
 
Safety Information
Hazard Codes  Xi,T
Risk Statements  36/37/38-61
Safety Statements  26-36-45-53
WGK Germany  3
TSCA  Yes
 
AICAR Usage And Synthesis
adenosine regulating agents Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate). 
Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.
Chemical Properties Solid
Uses glucose uptake stimulant; AMPK activator
Uses AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Definition ChEBI: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.
Biological Activity Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

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Company Profile Introduction

Meihua Biological Technology Co.,Ltd, is a global trading company, has been focusing on developing and manufacturing of advanced fine chemical and multiple intermediates. we are all members devoted to working in the filed for seven years. Rich experience gives us great enlightenments in founding of enterprise Meihua Biological Technology Co.,Ltd ,was established on the ground in 2011, is a collection, production, assay and sales into an integrated trading company in one of professional service and exported enterprise. As a mature manufacture, we have rigorous process flow. All final products come to us only by passing HPLC or GC assay. Through 30 procedures in all, we concentrate on every one gram of quality and every one milliliter of purity to your trust. We customize organic material,biochemical reagents,fine chemicals, pharmaceutical intermediates, OLED intermediates, liquid crystal intermediates and glucosides for customers, with high quality, competitive price, professional service and reliable source, and hundreds of species to choose. Such as 4-MPD/5F-ADB/2F-DCK/BK-EBDP/FUB-AMB/ADBF and so on, and new productions including 4433-77-6(BMK)/13605-48-6(PMK)16648-44-5(Benzeneacetic Acid ) etc. Of course, we support various transportation and safe payment. We are aiming at becoming a leading manufacture and trading company in China, even global. We are looking forward to establishing long-term cooperation relationship with customers in the word. We sincerely welcome to contact with us. For more information, please visit our website at http://www.hbmeihua.cn/

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