Doxorubicin hydrochloride

Price	$1
Package	1KG

Product Details

Product Name: Doxorubicin hydrochloride	CAS No.: 25316-40-9
Min. Order: 1G	Purity: 98%
Supply Ability: 100KG	Release date: 2019/07/06

AD68

Product Name:	Doxorubicin hydrochloride
Synonyms:	ADRIACIN;ADRIBLASTINA;ADRIBLASTINA HYDROCHLORIDE;ADRIAMYCIN HCL;ADRIAMYCIN HYDROCHLORIDE;(8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride;14-HYDROXYDAUNOMYCIN HCL;14-HYDROXYDAUNOMYCIN HYDROCHLORIDE
CAS:	25316-40-9
MF:	C27H30ClNO11
MW:	579.98
EINECS:	246-818-3
Product Categories:	APIs;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Pharmaceuticals;Antitumour;Adriamycin;inhibitor;Anti-cancer&immunity;Inhibitors
Mol File:	25316-40-9.mol

Doxorubicin hydrochloride Chemical Properties

Melting point	216 °C (dec.)(lit.)
alpha	D20 +248±2° (c = 0.1 in methanol)
storage temp.	2-8°C
solubility	H₂O: 10 mg/mL, clear, red-orange
color	orange to dark red
Water Solubility	Soluble in water.
λmax	497nm(H2O)(lit.)
Merck	14,3439
InChIKey	MWWSFMDVAYGXBV-RUELKSSGSA-N
CAS DataBase Reference	25316-40-9(CAS DataBase Reference)
EPA Substance Registry System	5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-. alpha.-L-lyxo-hexopyranosyl) oxy]-7,8,9,10-tetrahydro- 6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxy-, hydrochloride, (8S,10S)-(25316-40-9)

Safety Information

Hazard Codes	T,T+,Xi
Risk Statements	45-22-40-26/27/28-36/38
Safety Statements	53-45-36/37/39-22-7/9
WGK Germany	3
RTECS	QI9295900
F	10-21
HS Code	29419090
Toxicity	LD50 i.v. in mice: 21.1 mg/kg (Bertazzoli, 1970)

Doxorubicin hydrochloride Usage And Synthesis

Chemical Properties	Orange-Red Crystalline Solid
Uses	Used as an antineoplastic
Uses	Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.
Uses	Antibacterial;DNA intercalant
Uses	Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
Uses	Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumor agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
Uses	Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.[Cayman Chemical]
General Description	Orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9.
Air & Water Reactions	Water soluble.
Reactivity Profile	Amines, like Doxorubicin hydrochloride, are weak chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard	Doxorubicin hydrochloride is probably combustible.
Biological Activity	Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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