Aloe emodin

[product name] aloe emodin
[English name] Aloeemodin
[Chemical name] 1.8-Dihydroxy-3-[hydroxymethyl]-anthraquinone 1,8-Dihydroxy-3-hydroxymethylanthraquinone; 1,8-Dihydroxy-3-(hydroxymethyl) -9,10-anthracenedione;3-(Hydroxymethyl)chrysazin.
[Synonym] Rhabbarberone, Aloe Vera, Rottlerin
[Source] Rhizome of Rheumataceae Rheum palmatum L., rhizome of R. officinale Baill., rhizome of Rumex patientia L., leaf of R. dentatus L., leguminous family The root of the plant mountain lentils Cassia mimosoides L., the seed of Cassia C. tora L., the seed of C. occidentalis L., the fruit of the buckthorn plant ^b Rhamnus davurica Pall., the lily family Kula Aloe vera, aloe vera, aloe vera.
[Physical properties] Orange needle crystals (toluene), or khaki crystal powder. The melting point of 223 ~ 224 °, easy to sublimate. It is soluble in acetaldehyde, benzene, hot ethanol, dilute ammonia, sodium carbonate and sodium hydroxide. Soluble in hot ethanol. It is yellow in ether and benzene, and it is reddish in ammonia and sulfuric acid.
[Preparation method] Aloe-emodin can be obtained by extracting the crude product from aloe vera juice with a low-temperature dried product with ethyl acetate, and then purifying by silica gel column chromatography (petroleum ether-ethyl acetate).
[Specification]>90%;>98%, thin layer identification has only one spot, which is a single component.
[Storage] Store in a cool, dry place.

Pharmacological efficacy：

Antitumor activity
In recent years, domestic and foreign scholars are interested in the anti-tumor effect of aloe-emodin. The main anti-tumor activities are concentrated on tumors of neuroectodermal tumor, liver cancer, lung squamous cell carcinoma, skin Merkel cell carcinoma, gastric cancer and leukemia. A wide range of anti-cancer, aloe-emodin inhibits P388 leukemia cells and prolongs survival. One of its mechanisms of action is to inhibit the biosynthesis of DNA, RNA and proteins in cancer cells.
Antibacterial activity
At a concentration of 1.5～25mg/ml, aloe-emodin inhibits Staphylococcus, Streptococcus, Diphtheria, Bacillus subtilis, Anthrax, Paratyphoid bacillus, Shigella, etc. Among them, Staphylococcus and Streptococcus are most sensitive and bacteriostatic The effective concentration is 15-25 ug/ml. The antibacterial concentration of Staphylococcus aureus 209P, Escherichia coli and Shigella flexneri in vitro was 7.5mg/L and 600mg/L, respectively. The antibacterial effect was antibacterial rather than bactericidal. One of its mechanisms of action is to inhibit mitochondrial respiratory chain electron transport.
Aloe-emodin has a strong inhibitory effect on the nucleic acid and protein synthesis of Staphylococcus aureus. Aloe-emodin has a strong inhibitory effect on common clinical anaerobic bacteria. Among them, common fragile bacilli can inhibit the growth of 90%-100% strains, and its MIC is slightly higher than metronidazole. At a concentration of 8 μg/ml, 76% to 91% of anaerobic bacteria can be inhibited.
Immunosuppressive effect
Aloe-emodin can inhibit the production of antibodies in organisms, inhibit the clearance of carbon particles, reduce the weight of immune organs, reduce the number of white blood cells, and reduce the function of peritoneal macrophages. The concentration of [3H]-TDR and [3H]Urd in lymphocytes was significantly inhibited in vitro at a concentration of 100 μg/ml.
Laxative effect
Aloe-emodin has strong diarrhea activity, intestinal bacteria metabolism aloe emodin, rhein, and rhein ketone, the latter has a strong diarrhea effect. It is clinically used as a laxative with an appetite and laxative effect. According to the foreign medical journal, aloe vera is hydrolyzed into aloe-emodin under the action of parasites in the human body. This aloe-emodin stimulates the peristalsis of the intestinal wall, and at the same time, it is beneficial to the elimination of waste in the intestine due to the change of osmotic pressure, thereby achieving irritation. Laxative, this stimulating effect has a special effect on constipation and acne. Especially for middle-aged and elderly constipation, the treatment effect is more obvious.