D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL

 

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Basic information

Product Name:

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL

Synonyms:

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL;D(-)THREO-1-(4-NITRO-PHENYL)-2-AMINO-1,3-PROPANEDIOL;CHLORAMPHENICOL-WATER SOLUBLE;(1R,2R)-2-AMINO-1-(4-NITROPHENOL)PROPANE-1,3-DIOL;(1R,2R)-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL;(1R,2R)-2-AMINO-1-(4-NITROPHENYL)PROPANE-1,3-DIOL;D-(-)threo-2-amino-1-(p-nitrophenyl)propane-1,3-diol;CHLORAMPHENICOL BASE CRYSTALLINE

CAS:

MF:

C9H12N2O4

MW:

212.2

EINECS:

211-938-7

Product Categories:

Amino Alcohols (Chiral);Chiral Building Blocks;for Resolution of Acids;Optical Resolution;Synthetic Organic Chemistry;Antibiotics;-;Cell Culture;Reagents and Supplements

Mol File:

716-61-0.mol

 

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Chemical Properties

Melting point 

163-165 °C(lit.)

Boiling point 

352.03°C (rough estimate)

density 

1.3136 (rough estimate)

refractive index 

-30.5 ° (C=1, 6mol/L HCl)

storage temp. 

−20°C

form 

Powder

color 

Light yellow

optical activity

[α]25/D 30°, c = 1 in 6 M HCl

 

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

22-36/37/38-45

Safety Statements 

26-45-53-22

RIDADR 

UN 3259 8/PG 3

WGK Germany 

3

RTECS 

TY3100000

HS Code 

29221990

MSDS Information

 

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Usage And Synthesis

Chemical Properties

light yellow powder

Uses

D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is an impurity of Chloramphenicol (C325030), a broad spectrum antibiotic agent obtained from cultures of the soil bacterium Streptomyces venezuel ae.

Uses

Chloramphenicol base is the parent 4-nitrophenylpropylamine formed by the hydrolysis of the dichloroacetamide of chloramphenicol and is a degradation product commonly encountered with commercial production of chloramphenicol. Chloramphenicol base has no antibiotic activity but has played an integral role in the synthesis and SAR of new generation antibiotics, notably thiamphenicol and experimental analogues, bromamphenicol and methamphenicol.

Definition

ChEBI: A diol that is propane 1,3-diol bearing additional amino and 4-nitrophenyl substituents at positions 2 and 1 respectively.

 

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Preparation Products And Raw materials

Raw materials

Propiophenone