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Postion:Product Catalog > PeraMpanel

PeraMpanel

$7.00 / 1KG

  • 1KG
Min. Order: 1KG
Purity: 99%
Cas No.: 380917-97-5
Supply Ability: JD 474
Overview
  • Product Name: PeraMpanel
  • CAS No.: 380917-97-5
  • Min. Order:1KG
  • Purity:99%
  • Supply Ability:JD 474
  • Release date:2019/09/02
Product Advantage
Product Name:
PeraMpanel
Synonyms:
PeraMpanel;E 2007;ER 155055-90;PeraMpanel-D5;PeraMpanel-13C6;3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one;3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one;2-(2-oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile
CAS:
380917-97-5
MF:
C23H15N3O
MW:
349.3847
EINECS:
691-969-4
Product Categories:
API;Inhibitors;-
Mol File:
380917-97-5.mol
PeraMpanel Structure
 
PeraMpanel Chemical Properties
 
Safety Information
MSDS Information
 
 
PeraMpanel Usage And Synthesis
Description
Perampanel (licensed in 2012) is a third- generation AED known with the proprietary brand name of Fycompa® (Eisai, Hatfield) in the UK and Banzel® (Eisai, Hatfield) in the USA.
Indications
Epilepsy: Adjunctive treatment of focal seizures with or without secondary generalization and primary generalized tonic- clonic seizures.
Dose titration
Epilepsy— adjunctive therapy: 2 mg nocte for at least 14 days, then increased by 2 mg every 14 or more days; usual maintenance 4– 8 mg nocte (max. 12 mg nocte).
Interactions
With AEDs
  • Some AEDs known as CYP450 3A enzyme inducers (carbamazepine, oxcarbazepine, phenytoin) have been shown to increase perampanel clearance and consequently to decrease plasma concentrations of perampanel. Carbamazepine, a known potent enzyme inducer, reduced perampanel levels by two- thirds in a study performed on healthy subjects
  • In the epilepsy population pharmacokinetic analysis, perampanel was found to decrease the clearance of oxcarbazepine by 26%. Oxcarbazepine is rapidly metabolized by cytosolic reductase enzyme to the active metabolite, monohydroxycarbazepine. The effect of perampanel on monohydroxycarbazepine concentrations is not known.

With other drugs
  • Strong inducers of cytochrome P450, such as rifampicin and St John’s Wort (Hypericum perforatum), are expected to decrease perampanel concentrations.
  • In healthy subjects, the CYP3A4 inhibitor ketoconazole increases perampanel exposure.
  • Perampanel can make certain hormonal contraceptives such as levonorgestrel less effective.
  • Decrease in exposure of midazolam may be caused by perampanel.

With alcohol/food
  • Drinking alcohol while taking perampanel can affect a patients’ alertness and ability to drive or use tools or machines. It can also aggravate irritability, confusion, and depression.
  • There are no specific foods that must be excluded from diet when taking perampanel.
Special populations
Hepatic impairment
  • Increase at intervals of at least 2 weeks, up to a maximum of 8 mg daily, in mild- to- moderate impairment.
  • Avoid in severe impairment.

Renal impairment
Avoid in moderate or severe impairment.

Pregnancy
  • There are limited amount of data available on the use of perampanel in pregnant women and the potential risk for humans is unknown.
  • Perampanel is not recommended in pregnancy and female patients must use a reliable method of contraception to avoid becoming pregnant while being treated with perampanel (this should be continued for 1 month after stopping treatment).
  • As perampanel can make certain hormonal contraceptives such as levonorgestrel less effective, other forms of safe and effective contraception (such as a condom or coil) should be used when taking perampanel (this should be continued for 1 month after stopping treatment).
  • Perampanel has been found to be present in milk in animal studies and it is recommended that breastfeeding should be avoided.
  • Business model:Trader,Manufacturer
  • CB index: 58
  • Telephone: +86-371-86658258
  • Mobile: 13203830695
  • Address: No 70, Dianchang Road, Zhengzhou City, China

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