SU 5416

SU 5416 Basic information

Product Name:

SU 5416

Synonyms:

H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-;3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one;SeMaxinib;SU 5416 (SeMaxinib);SU5416 /SU-5416;(Z)-3-((3,5-diMethyl-1H-pyrrol-2-yl)Methylene)indolin-2-one;3-((3,5-diMethyl-1H-pyrrol-2-yl)Methylene)indolin-2-one;3-[(3,5-diMethyl-1H-pyrrol-2-yl)Methylidene]-1H-indol-2-one

CAS:

MF:

C15H14N2O

MW:

238.289

EINECS:

 

Product Categories:

Angiogenesis and Metastasis;Inhibitors;-

Mol File:

204005-46-9.mol

 

SU 5416 Chemical Properties

storage temp. 

−20°C

solubility 

H₂O: insoluble

form 

Yellow orange solid

color 

yellow to yellow orange

 

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29339900

MSDS Information

 

SU 5416 Usage And Synthesis

Uses

SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into t umor tissues.

Biological Activity

Inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Displays no activity against EGFR, HER2, IGF1R and PDGFR. Inhibits tumor vascularization and growth of multiple tumor types.

 

SU 5416 Preparation Products And Raw materials