LY-364947
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | 20kg |
| Update Time: | 2019-09-06 |
Product Details
| Product Name: LY-364947 | CAS No.: 396129-53-6 |
| Min. Order: 1KG | Purity: 98% |
| Supply Ability: 20kg | Release date: 2019/09/06 |
Abby020
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LY-364947 Basic information
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Product Name:
LY-364947
Synonyms:
LY-364947;[3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole;4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline;LY364947(HTS 466284);E 616451;HTS 466284;2-[4-(Quinolin-4-yl)-1H-pyrazol-3-yl]pyridine, 3-(Pyridin-2-yl)-4-(quinolin-4-yl)-1H-pyrazole;Quinoline, 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-
CAS:
396129-53-6
MF:
C17H12N4
MW:
272.31
EINECS:
Product Categories:
API;Inhibitors;Smad;TGF-beta
Mol File:
396129-53-6.mol
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LY-364947 Chemical Properties
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Melting point
>230℃ (dec.)
storage temp.
Store at RT
solubility
DMSO: soluble2mg/mL, clear
form
powder
color
white to beige
InChIKey
IBCXZJCWDGCXQT-UHFFFAOYSA-N
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Safety Information
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Hazard Codes
T,N
Risk Statements
25-36/37/38-50/53
Safety Statements
26-45-60-61
RIDADR
UN 2811 6.1/PG 3
WGK Germany
3
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MSDS Information
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LY-364947 Usage And Synthesis
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Biological Activity
Selective inhibitor of TGF- β type-I receptor (TGF- β RI, TGFR-I, T β R-I, ALK-5) (IC 50 values are 59, 400 and 1400 nM for TGR- β RI, TGF- β RII and MLK-7K respectively). Inhibits TGF- β -dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC 50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.
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LY-364947 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Zhengzhou High tech Zone, Henan Province, China
INQUIRY
杨俊青
sales@coreychem.com
sales@coreychem.com