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Postion:Product Catalog >API>Antineoplastic agents>Antimetabolites, Antineoplastic>Methotrexate
Methotrexate
  • Methotrexate

Methotrexate

Price
Package
Min. Order: 1KG
Supply Ability: 500 Ton/Tons per Month
Update Time: 2021-07-09

Product Details

Product Name: Methotrexate CAS No.: 59-05-2
Min. Order: 1KG Purity: 99.7%
Supply Ability: 500 Ton/Tons per Month Release date: 2021/07/09
Product Description

 

Methotrexate

Article illustration

Character

Methotrexate is a Orange yellow crystalline powder; the product hardly dissolves in water, ethanol, chloroform or ether, and it easily dissolves in dilute alkali, and it can dissolve in dilute hydrochloric acid.

Synonyms:

Methylaminopterin;Methylaminopterine;Antifolan;L-(+)-Amethopterin;(+)-Amethopterin;Amethopterin;4-Amino-N 10-Methylpteroyl-L-Glutamic Acid;4-Amino-1;Methylpteroylglutamic Acid;(+)-4-Amino-10-Methylfolic Acid;4-Amino-10-Methylfolic Acid;N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid;N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid;Mtx;4-Amino-4-Deoxy-N(Sup10;Methylpteroylglutamate;4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid;

CAS NO.:

59-05-2

Molecular Formula

C20H22N8O5

Formula Weight

454.44 

Execution Standard

CP2015,EP,USP

Packing Specification

0.5kg/bag;1kg/tin;5kg*2/barrel

Application

A Folic acid antagonist. Used as a antineoplastic and antirheumatic.

Used as anti-cancer drug.

 

Methotrexate Usage And Synthesis

Treatment of cancer and rheumatoid arthritis

Methotrexate is a drug used for the treatment of cancer, also known as cytotoxic drugs. In order to reduce its cytotoxicity, it can be used in conjunction with calcium leucovorin. It is primarily used for the treatment of acute leukemia (acute lymphocytic leukemia), breast cancer, malignant mole and choriocarcinoma, head and neck cancer, bone cancer, leukemia, spinal cord meningeal infiltration, lung cancer, reproductive system cancer, liver cancer, refractory psoriasis vulgaris, dermatomyositis, body myositis, ankylosing spondylitis inflammation, Crohn's disease, psoriasis and psoriatic arthritis, Behcet's disease and autoimmune disease. In Rheumatic Arthritis:
Methotrexate is an immunosuppressant and can be used for easing the process of rheumatism with a particularly excellent efficacy in treating synovial inflammation of rheumatoid arthritis and is the most frequently used drugs for treating rheumatoid diseases.

· Methotrexate (MTX), is one of first line DMARDs(disease-modifying antirheumatic drugs).The order of agent selection is not clearly defined, but MTX is often chosen initially because long-term data suggest superior outcomes compared with other DMARDs and lower cost than biologic agents.

· MTX inhibits cytokine production and purine biosynthesis, which may be responsible for its antiinflammatory properties. Its onset is relatively rapid (as early as 2 to 3 weeks), and 45% to 67% of patients remained on it in studies ranging from 5 to 7 years.

· Toxicities are GI (stomatitis, diarrhea, nausea, vomiting), hematologic (thrombocytopenia, leukopenia), pulmonary (fibrosis, pneumonitis), and hepatic (elevated enzymes, rare cirrhosis). MTX is contraindicated in pregnant and nursing women, chronic liver disease, immunodeficiency, pleural or peritoneal effusions, leukopenia, thrombocytopenia, preexisting blood disorders, and creatinine clearance <40 mL/min.

Company Profile Introduction

Company profile Hebei Xibaijie Biotechnology Co., Ltd has a registered capital of 3 million yuan and is one of the most dynamic foreign trade companies in the Chinese market. We have a pharmaceutical raw material production plant and a reagent R&D center. Now we have the most complete product line. In addition, we have developed and produced tens of thousands of reagents. Also we have the business of custom synthesis of various organic compounds as a supplement. We can synthesize almost all chemicals. Our goal is to survive by quality and develop by credit. After many years of efforts, we have established stable and friendly business relations with many of European and American pharmaceutical companies, multinational chemical companies and importers.At home and many production plants and research and development units have established long - term commission processing and production relations.We have a number of laboratories specializing in technology development and custom synthesis, as well as some production bases, mainly in hebei, dalian, jiangsu and guangzhou. Our company possesses the right of self-support import & export, a strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards. We put the quality management as the focus of enterprise management, to customer satisfaction for the purpose of the company, in order to ensure the quality of each batch of products to meet customer demand.We by strengthening employee training, improve the detection technology, perfect detection index to improve every aspect of quality control, improve the quality of the products.

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Hebei Linwo New Material Technology Co., LTD
2022-06-23
  • Since: 2019-07-05
  • Address: Federation business plaza, qiaoxi district, shijiazhuang city, hebei province
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