ASM-IN-1 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-21 |
Product Details
| Product Name: ASM-IN-1 | CAS No.: 2913151-46-7 |
| Supply Ability: 10g | Release date: 2025/07/21 |
Product Introduction
Bioactivity
| Name | ASM-IN-1 |
| Description | ASM-IN-1 is a potent, orally active inhibitor of acid sphingomyelinase (ASM) with an IC50 of 1.5 µM, demonstrating antiatherosclerotic and anti-inflammatory activity. It effectively reduces lipid plaques in the aortic arch and aorta, along with decreasing plasma ceramide concentrations and oxidized LDL (Ox-LDL) levels [1]. |
| In vitro | ASM-IN-1 (compound 4i) does not affect cell growth in HUVEC [1]. At concentrations of 0, 1, and 5 µM, ASM-IN-1 reduces IL-6 and TNF-α expression in HUVEC in a dose-dependent manner upon LPS stimulation [1]. Moreover, at 5 µM, ASM-IN-1 decreases MCP-1 mRNA expression and normalizes IL-6 mRNA levels in the presence of Ox-LDL [1]. |
| In vivo | ASM-IN-1, administered via intravenous injection at 1 mg/kg and orally at 10 mg/kg, demonstrated favorable pharmacokinetic properties in ICR mice with an oral bioavailability of 35.42% [1]. When given intraperitoneally at doses of 6, 12, and 40 mg/kg twice daily for a duration of 8 weeks, ASM-IN-1 exhibited anti-atherosclerotic activity by inhibiting ASM activity in mice [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Neomycin sulfate | 1-Naphthaleneacetic acid potassium salt | trans-Benzylideneacetone | Benzylideneacetone | Tris(2,4-di-tert-butylphenyl)phosphate | (E/Z)-Polydatin | Indomethacin | Fluticasone (propionate) | 1-Naphthaleneacetic acid | Darapladib | Lansoprazole | Amentoflavone |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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