BHPI NEW
| Price | $89 | $755 | $1240 |
| Package | 2mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-12-09 |
Product Details
| Product Name: BHPI | CAS No.: 56632-39-4 |
| Supply Ability: 10g | Release date: 2025/12/09 |
Product Introduction
Bioactivity
| Name | BHPI |
| Description | BHPI is a potent ERα inhibitor that blocks nuclear estrogen–ERα-regulated gene expression effectively. It triggers sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, notably the unfolded protein response (UPR), and consistently inhibits protein synthesis. With an IC50 value targeting ERα, BHPI's mechanism involves the rapid hyperactivation of PLCγ on the plasma membrane in ERα(+) cancer cells, which produces inositol 1,4,5-triphosphate (IP3). This, in turn, opens EnR IP3R calcium channels, leading to a rapid depletion of EnR Ca(2+) stores. SIGNIFICANTLY, BHPI alters estrogen-ERα's usual effect of causing mild and transient UPR activation by inducing a severe and prolonged UPR activation, transforming the UPR from a protective to a toxic response. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 4 mg/mL (12.07 mM), Sonication is recommeded. DMSO : 150 mg/mL (452.68 mM), Sonication is recommended. |
| Keywords | BHPI |
| Inhibitors Related | Neomycin sulfate | Tamoxifen | Kaempferol | Difluprednate | 2-Ethylhexyl trans-4-methoxycinnamate | Estradiol benzoate | Bisphenol B | Mequinol | Chlorothalonil | Ethisterone | Lansoprazole | Cholesterol |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1240.00/100mg |
VIP2Y
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TargetMol Chemicals Inc.
|
2025-07-19 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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