Bleomycin hydrochloride NEW
| Price | $37 | $87 | $137 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-05 |
Product Details
| Product Name: Bleomycin hydrochloride | CAS No.: 67763-87-5 |
| Purity: 98.00% | Supply Ability: 10g |
| Release date: 2025/11/05 |
Product Introduction
Bioactivity
| Name | Bleomycin hydrochloride |
| Description | Bleomycin hydrochloride is a glycopeptide antibiotic and a DNA synthesis inhibitor. Bleomycin Sulfate can cause DNA strand breaks but not RNA strand breaks. Bleomycin Sulfate has anti-tumor activity. |
| In vitro | METHODS: Human pancreatic cells (PCCs) AsPC-1 and MIA PaCa-2 were treated with Bleomycin Sulfate (0.1-100 µM) for 24-72 hours, and the cell growth inhibition was detected by the MTT method. RESULTS: AsPC-1 cells showed no response to Bleomycin Sulfate. Bleomycin Sulfate significantly inhibited the cell growth of MIA-PaCa-2, and the IC50 at 24/48/72 h was 5.9/6.4/2.6 μM, respectively. [1] METHODS : Mesenchymal stem cells (MSCs) were treated with Bleomycin Sulfate (1800 ng/mL) for 24-96 hours, and sub-G1 and caspase-3 were detected by Flow Cytometry. RESULTS: Bleomycin Sulfate induces upregulation of sub-G1 and caspase-3 activation, indicating that Bleomycin Sulfate induces apoptosis. [2] METHODS : Normal rat alveolar macrophages were incubated with Bleomycin Sulfate (0.01-1 μg/mL) for 18 hours, and their levels were determined using the MDGF Assay. RESULTS: Bleomycin Sulfate stimulates macrophages to produce fibroblast growth factor (MDGF). [3] |
| In vivo | METHODS: To detect the anti-tumor activity in vivo, Bleomycin Sulfate (20 mg/kg) was intraperitoneally injected into BALB/c mice carrying mouse colorectal cancer tumor CT26 shControl or shCRT, once every two days for five times. RESULTS: Bleomycin Sulfate delayed the growth of CT26 cells transfected with control shRNA, but had no effect on CT26 cells transfected with CRT shRNA. [4] METHODS: To study the time course of Bleomycin induced pulmonary fibrosis in mice, Bleomycin Sulfate (0.06 mg/ mouse in 0.9% saline) was administered as a single intratracheal instillation (IT) to C57Bl/6J mice. RESULTS: Bleomycin Sulfate induced pulmonary fibrosis in mice. The most appropriate time point for evaluating pulmonary fibrosis in this model is 14 days after IT infusion of Bleomycin Sulfate. This is based on the observation that extensive fibrosis occurred in animals at 14 days, but the variability of the fibrotic response was smaller and the mortality rate was lower than 21 days. [5] |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 255 mg/mL, Sonication and heating to 60℃ are recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL, Sonication is recommended. H2O : 80 mg/mL (55.13 mM), Sonication is recommended. |
| Keywords | RNASynthesis | RNA Synthesis | DNASynthesis | DNA Synthesis | DNA synthesis | Bleomycinhydrochloride | Bleomycin Hydrochloride |
| Inhibitors Related | 5-Fluorouracil | Procaine | Rifaximin | Capecitabine | Ribavirin | Guanidine hydrochloride | Methotrexate disodium | Cytarabine | Acyclovir | Thymidine | Cisplatin | Folic acid |
| Related Compound Libraries | Antibiotics Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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