Product Details
| Product Name:
Bufuralol |
CAS No.:
54340-62-4 |
| Purity:
98.26% |
Supply Ability:
10g |
| Release date:
2025/11/05 |
Product Introduction
Bioactivity
| Name | Bufuralol |
| Description | Bufuralol (Ro 3-4787) is an orally active β-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases. |
| In vitro | Bufuralol is a widely used substrate for assessing cytochrome P450 2D6 (CYP2D6) enzyme activity. By measuring the rate of metabolism of Bufuralol, the level of CYP2D6 activity in an individual or cell can be effectively assessed. [1] |
| In vivo | The metabolism of Bufuralol is mediated by NADPH-dependent cytochrome P450 enzymes (specifically CYP2D6) and exhibits biphasic kinetics. The metabolic efficiency of Bufuralol was significantly increased in the intestines of monkeys in the presence of hydroperoxyisopropylbenzene (CuOOH). The metabolism of Bufuralol exhibited biphasic kinetics mediated by NADPH and was more efficient in the presence of CuOOH, which was consistent with observations in the liver. [2] |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (12.63 mM), Sonication is recommended.
DMSO : 80 mg/mL (306.09 mM.), Sonication is recommended.
|
| Keywords | β-adrenergic Receptor | Bufuralol | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Olanzapine | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Phenylephrine hydrochloride | Amitriptyline hydrochloride | Isoprenaline hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Doxepin hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States