Cabozantinib Malate
| Price | Get Latest Price |
| Package | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | 100kg |
| Update Time: | 2023-03-12 |
Product Details
| Product Name: Cabozantinib Malate | CAS No.: 1140909-48-3 |
| EC-No.: 691-711-0 | Min. Order: 1kg |
| Purity: 98.0%min | Supply Ability: 100kg |
| Release date: 2023/03/12 | |
| Package: foil bag; fibber/steel drum; glass bottle etc. | Shipment: professional agent on courier, air, sea |
| Contact: marsha@lychems.cn |
| Cabozantinib Malate Basic information |
| Pharmacological effects Precautions |
| Product Name: | Cabozantinib Malate |
| Synonyms: | 1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide,(2S)-2-hydroxybutanedioic acid;Smalate;XL184(S)-malate;N-(2-{[(3R)-1-(4-CHLOROBENZYL)-3-PYRROLIDINYL]AMINO}-2-OXOETHYL)-3-(TRIFLUOROMETHYL)BENZAMIDE HYDROCHLORIDE (1:1);Cabozantinib (XL184) S-malate;Cabozantinib malate, 98%, a potent VEGFR2 inhibitor;Carbozanitinb Malate;(2S)-2-Hydroxybutanedioic acid compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1) |
| CAS: | 1140909-48-3 |
| MF: | C32H30FN3O10 |
| MW: | 635.6 |
| EINECS: | 691-711-0 |
| Cabozantinib Malate Chemical Properties |
| Melting point | 166-169°C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly) |
| form | Solid |
| color | White to Off-White |
| Uses | Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell a poptosis. |
| Uses | XL184 (Cabozantinib, BMS-907351) is a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. |
| Uses | Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. |
Company Profile Introduction
LY Global Chemicals Co Ltd.. is a limited liability company specialized in technical research and development, production, development and trade of chemical products. Mainly engaged in the customization and sales of pharmaceutical intermediates, electronic materials, cosmetics raw materials and other fine chemicals. We have many years of export experience, and our customers are all over many countries. Our products are of good quality, competitive price, stable supply, and customers are very satisfied
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