Ciprofloxacin NEW
| Price | $41 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: Ciprofloxacin | CAS No.: 85721-33-1 |
| Purity: 99.22% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | Ciprofloxacin |
| Description | Ciprofloxacin (Bay-09867) mainly targets bacterial DNA Gyrase (IC50=0.22-0.31 µM) and topoisomerase IV (IC50=0.3-1.9 µM). Ciprofloxacin is a highly active fluoroquinolone antibiotic. |
| Kinase Assay | The in vitro kinase assays is performed by incubating purified kinase (IKKε or TBK1) in kinase buffer containing 25 mM Tris (pH7.5), 10 mM MgCl2, 1 mM DTT, and 10 μM ATP for 30 minutes at 30°C in the presence of 0.5 μCi γ-[32P]-ATP and 1 μg MBP per sample as a substrate. The kinase reaction is stopped by adding 4x sodium dodecyl sulfate (SDS) sample buffer and boiling for 5 minutes at 95°C. Supernatants are resolved by SDS-polyacrylamide gel electrophoresis, transferred to nitrocellulose, and analyzed by autoradiography using a Typhoon 9410 phosphorimager. |
| In vitro | METHODS: Prostate cancer cells (LNCaP and DU145) were treated with Ciprofloxacin, and the cytotoxicity was detected by lactate dehydrogenase (LDH) release assay. RESULTS: Ciprofloxacin showed low cytotoxicity to DU145 cells, with a LDH release rate of 23.3%. The release rate of LDH to LNCaP cells was 22.1%. [1] METHODS: Tenocytes were treated with Ciprofloxacin (5-50 μg/mL) for 0-24 hours, and MTT assay was used to detect cell growth inhibition. RESULTS: Ciprofloxacin inhibited cell proliferation and induced cell cycle arrest at G2/M phase. [2] METHODS: Minimum inhibitory concentrations of Yersinia pestis and Bacillus anthracis were determined after treatment with Ciprofloxacin. RESULTS: Ciprofloxacin showed potent activity against Yersinia pestis and Bacillus anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively. [3] |
| In vivo | METHODS: To study the preventive effect of Ciprofloxacin against plague, mice were intraperitoneally injected with Ciprofloxacin (30 mg/kg) for 24 hours. RESULTS: Ciprofloxacin could prevent Yersinia pestis in a mouse model of pneumonic plague. [4] METHODS: To investigate the effect of Ciprofloxacin on the susceptibility to aortic dissection and rupture in mice, Ciprofloxacin (100 mg/kg) was administered intraperitoneally once daily for 4 weeks. RESULTS: Ciprofloxacin accelerated aortic root dilation and increased the incidence of aortic dissection and rupture by decreasing LOX levels and increasing MMP levels and activity in the aortic wall. Ciprofloxacin induces DNA damage and release of DNA into the cytoplasm, mitochondrial dysfunction, and activation of cytoplasmic DNA sensor signals. Ciprofloxacin increased apoptosis and necroptosis in the aortic wall. [5] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : Insoluble DMSO : 0.33 mg/mL (1 mM), Sonication is recommended. 0.1 M HCl : 55 mg/mL (165.99 mM), Sonication and heating are recommended.The compound is unstable in solution. Please use sonn. 0.1 M HCL : 55 mg/mL (165.99 mM), Sonication and heating are recommended.The compound is unstable in solution. Please use sonn. |
| Keywords | Topoisomerase | Topo IV | Topo II | ROS | Reactive Oxygen Species | Mitochondrial Metabolism | mitochondrial | Inhibitor | inhibit | DNA damage | DNA | Ciprofloxacin | Bay09867 | Bay 09867 | Bacterial | Apoptosis | anti-proliferative | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Ethoxyquin | Cysteamine hydrochloride | Adipic dihydrazide | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Copper(Ⅱ) Sulfate | Tributyrin | Alginic acid | Dextran sulfate sodium salt (MW 5000) | BES |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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