cRIPGBM chloride NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: cRIPGBM chloride | CAS No.: 2361988-77-2 |
| Supply Ability: 10g | Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | cRIPGBM chloride |
| Description | cRIPGBM chloride is an apoptosis-promoting derivative present in GBM cancer stem cells with antitumor activity. It induces caspase-1 dependent cell apoptosis by interacting with receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch. cRIPGBM chloride reduces the formation of pro-survival RIPK2/TAK1 complexes and increases the formation of pro-apoptotic RIPK2/caspase 1 complexes, which can be used to study brain tumors. |
| In vitro | cRIPGBM chloride induces Caspase-1 dependent apoptosis by binding to receptor interacting protein kinase 2 (RIPK2) and acting as a molecular switch, EC50 = 68 nM. Thus, the formation of pro-survival RIPK2/TAK1 complex was decreased and the formation of pro-apoptotic RIPK2/caspase 1 complex was increased. [1] |
| In vivo | In a mouse model of intracranial GBM CSC tumor xenotransplantation in situ, cRIPGBM chloride (20 mg/kg oral) was found to significantly inhibit tumor formation in vivo. [1] |
| Storage | store at low temperature | Shipping with blue ice. |
| Solubility Information | DMSO : 16 mg/mL (35.8 mM), Sonication is recommended. |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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