Exendin-4 NEW
| Price | $57 | $83 | $137 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-06 |
Product Details
| Product Name: Exendin-4 | CAS No.: 141758-74-9 |
| Purity: 99.78% | Supply Ability: 10g |
| Release date: 2025/11/06 |
Product Introduction
Bioactivity
| Name | Exendin-4 |
| Description | Exendin-4 (Exenatide) is a glucagon-like peptide-1 receptor (GLP-1) agonist (IC50: 3.22 nM). Exenatide is a 39 amino acid peptide. Compared to GLP-1, exenatide has a longer half-life of 2.4 hours. |
| In vitro | In HUVECs, exendin-4 dose-dependently significantly increases NO production, eNOS phosphorylation and GTPCH1 level[2]. Exendin-4 shows cytotoxic effects to MCF-7 breast cancer cells (IC50 5 μM) at 48 hours [3]. |
| In vivo | In ob/ob mice, the treatment of exendin-4 improve serum ALT and reduce serum glucose, insulin levels and calculated HOMA scores compared with control. In the final 4 weeks of the study period, exendin-4-treated ob/ob mice sustain an obvious reduction in the net weight gain[4]. Animals treated with exendin-4 have more pyknotic nuclei, more pancreatic acinar inflammation and weigh significantly less than control rats[5]. Exenatide leads to dose-dependent relaxation of rat thoracic aorta, which is evoked via the GLP-1 receptor and is mediated mainly by H2S but also by CO and NO[6]. |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (0.48 mM), Sonication is recommended. DMSO : 10 mM, Sonication is recommended. H2O : 1.23 mg/mL (0.29 mM), Sonication and heating are recommended. |
| Keywords | GlucagonReceptor | glucagon-like peptide-1 receptor | Glucagon Receptor | Exendin-4 | Exendin4 | Exendin 4 | 141732-76-5 |
| Inhibitors Related | PF-06882961 Tris | L-168049 | PF-06882961 | Glucagon (1-29), bovine, human, porcine hydrochloride | (S, R)-LSN 3318839 | NNC 92-1687 | Adomeglivant | Bay 55-9837 acetate | 6α-Methylprednisolone 21-hemisuccinate sodium salt | Orforglipron | Tirzepatide Acetate(2023788-19-2 free base) | LSN3318839 |
| Related Compound Libraries | ReFRAME Related Library | NO PAINS Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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