Product Details
| Product Name:
Guadecitabine |
CAS No.:
929901-49-5 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | Guadecitabine |
| Description | Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes. |
| In vitro | Exposure to Guadecitabine significantly enhances the expression levels of HLA class I antigens, specifically HLA-A2 allospecificity, and the co-stimulatory molecule ICAM-1 in Mel 275 melanoma cells, indicating an upregulation (p<0.05). Additionally, it notably reduces the methylation levels of CTA promoters in the cancer cells studied, leading to a significant decrease (p<0.01). This exposure also stimulates the expression of previously non-expressed cancer/testis antigens in CTA-negative cancer cells and markedly increases MAGE-A3- and NY-ESO-1-specific mRNA expression across all investigated neoplastic cell histotypes. Furthermore, Guadecitabine's induction of demethylation in MAGE-A1 and NY-ESO-1 promoters shows mean values of 57% and 30% in Mel 195 cells, and 22% and 33% in MZ-1257 RCC cells, respectively. |
| In vivo | Guadecitabine effectively inhibits tumor growth with significantly lower toxicity levels, as evident through less weight change in mice, when administered subcutaneously (SQ) compared to intraperitoneal (IP) injections. Although Guadecitabine does not reduce tumor size, it markedly restricts their growth, in contrast to tumors receiving only PBS, which exhibit considerable enlargement [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : Soluble
|
| Keywords | SGI110 | SGI 110 | Guadecitabine | DNA Methyltransferase |
| Inhibitors Related | Decitabine | GSK-3484862 | Levetiracetam | Dihydro-5-azacytidine FA | 5-Azacytidine | CBHcy | Procainamide hydrochloride | SW155246 | Zebularine | γ-Oryzanol | 6-Thioguanine | TFMB-(S)-2-HG |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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$2180.00/50mg |
VIP4Y
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TargetMol Chemicals Inc.
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2025-07-16 |
United States