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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Metabolism>PPAR agonists>GW-0742
GW-0742
  • GW-0742

GW-0742

Price Get Latest Price
Package 1KG
Min. Order: 0.01KG
Supply Ability: 1 tons
Update Time: 2022-04-01

Product Details

Product Name: GW-0742 CAS No.: 317318-84-6
Min. Order: 0.01KG Purity: 99%
Supply Ability: 1 tons Release date: 2022/04/01





1. Name: GW-0742

2. Other Name: GW610742

3. CAS: 317318-84-6

4. Molecular Formula:C21H17F4NO3S2

5. Formula Weight:471.5

6. appearance:white solid

7.  Mp:134.5-135.5 °C


Gw0742 Description:


1. GW0742 is a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.


2. A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit

 

3. the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator.


4. These inhibitors represent novel molecular probes to modulate gene regulation mediated by VDR. The peroxisome proliferator-activated receptor δ (PPARδ) agonist GW0742 was among the identified VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µM.


5. The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations.


6. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner.


7. The GW0742-inhibited NR-coactivator binding resulted in a reduced expression of five different NR target genes in LNCaP cells in the presence of agonist. Especially VDR target genes CYP24A1, IGFBP-3 and TRPV6 were negatively regulated by GW0742.


8. GW0742 is the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists. Nevertheless, the VDR-meditated downstream process of cell differentiation was antagonized by GW0742 in HL-60 cells that were pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.


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Article illustration



Whatsapp / Skype : +86 18986015478

Wickr: Amygodbullraw

Email: Amysales@godbullraw.com


FAQ:

Q1: Do you offer free sample?

A: Of course, we will offer free sample if you pay shipping fees.


Q2: How to solve the quality problem?

A: We supply high quality products and quality issue near to zero. If it happens caused by occasional?case, we will reship again or compensate customer loss, but customer need show us the evidence of problems or test report.


Q3: Whether transportation is safe and whether to reship if seized?

A: Yes, we offer almost 100% Shipping line with safe delivery. If seized unfortunately, we will ship and I am sure no custom issue.


Q4: ETA ?

A: Pack sent out in 2-3 days and offer tracking numbers after payment. ETA not the same decide by destination country. Please contact us for details (always 10-15 days).


Q5: Do you have any discount?

A: The price is negotiable. Plz shoot us your order content, we will quote a fair price.


Q6: What is your minimum order ?

A: Usually MOQ is 100g. But depends on the items and your requirements, we also can support small quantity, such as 20g and 50g.


Q7: How to order?

A: E-mail or message us that includes your order like format below:

product A ? 100g

product B ? 10vials

delivery country:?

Our sales will quote a total cost includes shipping fees and each item fees in 12 hours regularly.?

Our will satisfy your purchase and supply professional guide.






Company Profile Introduction

Wuhan Godbullraw Chemical Co.,ltd, founded in 2011, is a modern advanced enterprise specializing in custom synthesis and R&D and exportation of APIs, peptides, Sarms, Local anesthetics, plant extract etc, we build coopration with labs and factory qualitied with GMP, DMF, FDA in china and worldwild. We take advantage on integrating factory resources and lab customized projects.for customer demand, we continue to expand the industry chain in familiar areas, and at the same time we also keep develop new product supply chain.

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  • Since: 2016-06-27
  • Address: #58, Guanggu avenue, East Lake High-tech district , Wuhan, Hubei, China
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