IRG1-IN-1 NEW
| Price | $54 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-13 |
Product Details
| Product Name: IRG1-IN-1 | CAS No.: 2407652-42-8 |
| Purity: 99.36% | Supply Ability: 10g |
| Release date: 2025/10/13 |
Product Introduction
Bioactivity
| Name | IRG1-IN-1 |
| Description | IRG1-IN-1, an itaconic acid derivative, inhibits Immune Response Gene 1 (IRG1) activity and is suitable for cancer, inflammation, and autoimmune disease research. |
| In vitro | IRG1-IN-1 (0.5 mM; 1 mM) partially inhibits the proliferation of C-IRG1-9 rat glioma cells [1]. IRG1-IN-1 (0.5 mM; 2 mM) reduces the production of itaconic acid and the secretion of TNFα from human monocyte-derived macrophages (hMDMs) stimulated with LPS [1].IRG1-IN-1 (10μM) shows a decrease in trimethylation of histone 3 at lysine 4 (H3K4me3) in CR-activated hCD8+ T cells [1]. IRG1-IN-1 (10 nM) increases the proliferation of TCR-activated hCD8+ T cells [1]. |
| In vivo | IRG1-IN-1 administered intraperitoneally at a dose of 0.2 mg/kg for 27 days demonstrates a significant anti-tumor effect in C57BL/6 mice [1]. |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (254.53 mM), Sonication is recommended. |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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