L-Thyroxine NEW

Chinese name: L-thyroxine

English name :L-Thyroxine

CAS:51-48-9

EINECS number :200-101-1

Molecular formula :C15H11I4NO4

MDL number :MFCD00002596

Molecular weight :776.87

Appearance: white crystal. Mp235-236℃(decomposition), specific rotation [α]20D-4.4°(3%, 0.13 mol/L sodium hydroxide, 70% ethanol), the maximum absorption at 325nm wavelength in 0.4mol/L NaOH solution, and the maximum absorption at 295nm wavelength in 0.4mol/L HCl solution. This product is soluble in alkali solution, insoluble in water, ethanol and ether.

Melting point :235 °C

Specific rotation :-5 º (1N NaOH:EtOH 1:2)

Density :2.4440 (estimate)

Flash point :9℃

Storage conditions :2-8°C

Solubility: 50mg/ml dissolved in 4M ammonium hydroxide methanol solution

Boiling point :576.3±50.0 °C(Predicted)

Acidity factor (pKa):2.2(at 25℃)

Form: Powder

Color: White to light brown

Water solubility :insoluble

Sensitivity: light sensitive

Merck:9491

BRN:2228515

InChIKey:XUIIKFGFIJCVMT-LBPRGKRZSA-N

Use 1

Biochemical research; Thyroxine drugs.

Preparation method

3, 5-diiodo-L-tyrosine was used as the main raw material.