Product Details
| Product Name: Melanotan-1 | CAS No.: 75921-69-6 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: 1T | Release date: 2025/10/22 |
| Product Name: | Melanotan-1 |
| Synonyms: | [NLE4,D-PHE]ALPHA-MELANOCYTE STIMULATING HORMONE;(NLE4,D-PHE7)-ALPHA-MSH;[Nle4,D-Phe7]α-MSH;Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2;N-Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2;[Nle4,DPhe7] a-MSH, amide;[Nle4,DPhe7] a-MSH, amide:Melanotan Ⅰ;[Nle4, D-Phe7]-α-MSH, amide |
| CAS: | 75921-69-6 |
| MF: | C78H111N21O19 |
| MW: | 1646.85 |
| EINECS: | 211-519-9 |
| Product Categories: | Ion Channel Modulating Peptides;Melanocyte Stimulating Hormones (MSH);ImmunomodulatorsHormones;Obesity Research;Peptides for Cell Biology;Pituitary Hormones;Peptide;Melanocyte Stimulating Hormone (MSH)Peptides and Proteins;α-Melanocyte Stimulating Hormone (α-MSH)Peptides for Cell Biology;Cytokines Growth Factors and Hormones (Obesity);Melanotan II A |
| Mol File: | 75921-69-6.mol |
 | |
| Melanotan-1 Chemical Properties |
| density | 1.46±0.1 g/cm3(Predicted) |
| RTECS | OS1830200 |
| storage temp. | −20°C |
| solubility | 0.1% aqueous TFA: 1.00-1.04mg/mL, clear, colorless |
| pka | 4.43±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| biological source | synthetic (organic) |
| Water Solubility | Soluble to 0.60 mg/ml in sterile water |
| Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| InChIKey | UAHFGYDRQSXQEB-LEBBXHLNSA-N |
| CAS DataBase Reference | 75921-69-6(CAS DataBase Reference) |
| Safety Information |
| WGK Germany | 3 |
| MSDS Information |
| Melanotan-1 Usage And Synthesis |
| Features | Afamelanotide is a potent, linear synthetic analog of the naturally occurring peptide hormone α-melanocyte-stimulating hormone (α-MSH).Modified to have a stronger binding affinity to melanocortin- 1 receptor (MC1R) and a smaller disassociation constant, afamelanotide has a longer half-life and subsequently exerts longer pharmacologic activity than its parent hormone. |
| Uses | Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes. |
| Definition | ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug. |
| Origin | Melanotan 1, an alpha MSH analog (Nle4DPhe7-Melanocyte-Stimulating Hormone), is a potent melanocortin developed in the 1980s. Melanotan 2 is a shorter cyclic variant of Melanotan 1 produced in the 1990s. Melanotan 2 was found to increase skin pigmentation at lower cumulative doses than Melanotan 1. However, in clinical trials it was found to have more side effects including nausea somnolence and penile erections[1]. |
| References | [1] Robert T Dorr. “Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers.” Archives of dermatology 140 7 (2004): 827–35. |
| General Description | [Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation. |
| Biochem/physiol Actions | [Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases. |
| Side effects | The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections. |
| storage | Store at -20°C |
Company Profile Introduction
Shandong Hanjiang Chemical Co., Ltd. is located in Zibo City, Shandong Province, China.
It is a biotechnology enterprise engaged in the R&D, production and sales of drugs, steroids, peptides, raw materials, vitamins, food additives, animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. Advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, and its products are exported to countries all over the world. It has won a good international reputation for its excellent quality and excellent service. The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, and constantly strict requirements,
Advantages:
1. Samples are provided for test;
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Our company Superiority
1 Best service, high quality and reasonable price
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4. Specials are possible when client's order is big enough, including the discount policy;
5.Our company promise to deliver clients' package to his hands safely, or we'll cover the total loss and reship in time;
Our company supply high quality chemical products with the most competitive prices.
If have any need or question, contact us freely.
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