Nicotinamide NEW
| Price | $29 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-11 |
Product Details
| Product Name: Nicotinamide | CAS No.: 98-92-0 |
| Purity: 99.78% | Supply Ability: 10g |
| Release date: 2025/11/11 |
Product Introduction
Bioactivity
| Name | Nicotinamide |
| Description | Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra. |
| In vitro | METHODS: A375, SK-MEL-28, and mouse B16-F10 cells were treated with Nicotinamide (0, 1, 20, and 50 mM) for 24 or 48 hours. RESULTS: Nicotinamide reduced cell numbers ina dose-dependent manner, with a strong inhibitory effect at 20mM and almost full effect at 50mM. [1] |
| In vivo | METHODS: To study the anti-tumor activity of Nicotinamide, mice were intraperitoneally injected with Nicotinamide (1500 and 1800 mg/Kg, 5 days a week). RESULTS: Nicotinamide inhibited tumor growth ina mouse model of metastatic melanoma. [1] METHODS: To study the antiviral activity of Nicotinamide, Nicotinamide (0-200 mg/kg, 5 days) was intraperitoneally injected into HBV transgenic mice. RESULTS: Nicotinamide inhibited HBV replication in HBV transgenic mice. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 260 mg/mL (2129.05 mM), Sonication is recommended. Ethanol : 23 mg/mL (188.34 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (40.94 mM), Sonication is recommended. H2O : 122.7 mg/mL (1004.75 mM), Sonication is recommended. |
| Keywords | skin cancer | Sirtuin | SIRT | Nicotinamide | Murine metastatic melanoma model | Melanoma | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | A375 cell |
| Inhibitors Related | Sucrose | Aceglutamide | Emtricitabine | 3-Hydroxybutyric acid sodium | Levulinic acid | D(+)-Raffinose pentahydrate | D-(+)-Trehalose dihydrate | Glycerol | Thymidine | Sodium 2-hydroxybutanoate | Chitosan oligosaccharide | 3-Indoleacetic acid |
| Related Compound Libraries | Drug Repurposing Compound Library | Cosmetic Ingredient Compound Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Gut Microbial Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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