Olprinone Hydrochloride NEW
| Price | $33 |
| Package | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Olprinone Hydrochloride | CAS No.: 119615-63-3 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Olprinone Hydrochloride |
| Description | Olprinone Hydrochloride, also known as Loprinone, is a phosphodiesterase (PDE) 3 potent inhibitor, exhibiting IC50 values of 150, 100, 0.35, and 14 μM for PDE1, PDE2, PDE3, and PDE4, respectively. It is utilized in heart failure research for its positive inotropic and vasodilative properties. It also exhibits anti-inflammatory activity [1] [2]. |
| In vivo | Olprinone (Loprinone) Hydrochloride (0.2 mg/kg; i.p.) effectively mitigates inflammation and reduces myocardial damage in ischemia-reperfusion injury within male adult Wistar rats (250-300 g) designated as ischemia–reperfusion models. Administered intraperitoneally 15 minutes post-ischemia, it markedly lowers histologic signs of cardiac injury, diminishes levels of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), decreases expression of adhesion molecules such as Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, reduces nitrotyrosine formation, suppresses nuclear factor kappa-B (NF-κB) expression, curtails Poly (ADP-ribose) (PAR) formation, and lessens apoptosis, as evidenced by alterations in Bax, Bcl-2, Fas-L levels and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL) outcomes. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Olprinone Hydrochloride |
| Inhibitors Related | Balipodect | Theophylline monohydrate | Roflumilast | Luteolin | Theobromine | Apremilast | Isoprenaline hydrochloride | Indomethacin | Icariin | Vardenafil hydrochloride | Doxofylline | Sildenafil citrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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