Product Details
| Product Name:
Peruvoside |
CAS No.:
1182-87-2 |
| Purity:
98.96% |
Supply Ability:
10g |
| Release date:
2026/04/21 |
Product Introduction
Bioactivity
| Name | Peruvoside |
| Description | Peruvoside (Encordin) is a natural cardiac glycoside that inhibits Na+/K+-ATPase to increase myocardial contractility; causes cell cycle arrest in leukemia stem cells at the G₂/M phase, and; inhibits NSCLC cell growth as a Src inhibitor; and induces apoptosis in cancer cells through MAPK Wnt / β-catenin and PI3K / AKT / mTOR . |
| In vitro | Methods: A549 lung cancer cell line was treated with Peruvoside (5, 10, 50 nM, 24 hours), and the expression of related proteins was analyzed by Western Blot.
Results: Peruvoside inhibited the protein expression and phosphorylation of Src, EGFR and STAT3 in A549 cells. [1] |
| In vivo | Methods: Nude mice with A549 cell subcutaneous xenografts were treated with Peruvoside (0.1 mg/kg, intraperitoneal injection, daily, for 28 days). Tumor growth was then monitored every 7 days.
Results: The mean tumor size in the Peruvoside-treated group was 129.9 mm³ (95% CI = 86-174 mm³; P = 0.0068), which was significantly smaller than that in the control group (348 mm³, 95% CI = 189-507 mm³). The tumor weight was also significantly reduced, from 0.55 g in the control group to 0.26 g in the Peruvoside-treated group (P = 0.0126). [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 200 mg/mL (364.52 mM), Sonication and heating are recommended.
|
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Ethyl linoleate | Formamide | Paeonol | Naringin | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/25kg |
|
Shaanxi Haibo Biotechnology Co., Ltd
|
2023-08-25 |
United States