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Postion:Product Catalog >Organic Chemistry>Amides>Amides>Phenacetin
Phenacetin
  • Phenacetin
  • Phenacetin
  • Phenacetin
  • Phenacetin
  • Phenacetin

Phenacetin NEW

Price $15
Package 1KG
Min. Order: 1KG
Supply Ability: large quantity
Update Time: 2024-01-18

Product Details

Product Name: Phenacetin CAS No.: 62-44-2
Min. Order: 1KG Purity: 99%
Supply Ability: large quantity Release date: 2024/01/18

WhatsApp:+8613043004613

Telegram: @Sara2215

Email: Sara@xmwonderfulbio.com

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Article illustration




Common NamePhenacetin
CAS Number62-44-2Molecular Weight179.216
Density1.0±0.1 g/cm3Boiling Point323.6±44.0 °C at 760 mmHg
Molecular FormulaC10H13NO2Melting Point133-136 °C(lit.)
MSDSChineseUSAFlash Point149.5±28.4 °C
SymbolArticle illustration Article illustration
GHS07, GHS08
Signal WordDanger




Use of Phenacetin


Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity.Target: COXPhenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy. the clinical and laboratory data were compatible with "phenacetin nephritis" as described in Europe and Australia and recently in the United States and Canada. This report evaluates the findings in the 23 cases and cautions against the use of phenacetin, particularly in patients with impaired renal function [1]. Phenacetin has been linked to renal papillary necrosis in human beings [2, 3].






Phenacetin Biological Activity

DescriptionPhenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity.Target: COXPhenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy. the clinical and laboratory data were compatible with "phenacetin nephritis" as described in Europe and Australia and recently in the United States and Canada. This report evaluates the findings in the 23 cases and cautions against the use of phenacetin, particularly in patients with impaired renal function [1]. Phenacetin has been linked to renal papillary necrosis in human beings [2, 3].
Related Catalog
Research Areas >> Inflammation/Immunology
Target

COX-3:102 μM (IC50)

References

[1]. Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13926-31.

[2]. Brix, A.E., Renal papillary necrosis. Toxicol Pathol, 2002. 30(6): p. 672-4.

[3]. Dubach, U.C., B. Rosner, and T. Sturmer, An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987). N Engl J Med, 1991. 324(3): p. 155-60.




 

Chemical & Physical Properties

Density1.0±0.1 g/cm3
Boiling Point323.6±44.0 °C at 760 mmHg
Melting Point133-136 °C(lit.)
Molecular FormulaC10H13NO2
Molecular Weight179.216
Flash Point149.5±28.4 °C
Exact Mass179.094635
PSA38.33000
LogP2.01
Vapour Pressure0.0±0.7 mmHg at 25°C
Index of Refraction1.506
StabilityStable. Incompatible with strong oxidizing agents, strong acids.
Water Solubility0.076 g/100 mL





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FAQ:

 

1: Can I have a sample order for your products?

 

Yes, we can supply the free sample, but the shipping cost be paid by our customers.

 

 

2: How to confirm the Product Quality before placing orders?

 

1) You can get free samples for some products, just pay the basic cost for us.

2) Also you can send the specification or your request to us, we will customize the products for you.

 

 

3: How do you deal with quality complaints?

 

A: first of all, our quality control will reduce the quality problem to nearly zero. If the actual quality problem is caused by us, we will send you free goods for replacement or refund.

 

 

4: Can you give me a discount?

 

A: Of course, it depends on your quantity.

 

 

5:Are you a trading company or a manufacturer?

 

We are both, so we can always provide wholesale price and most products in stock.

 

 

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You can chat with us by Whatsapp ,Telegram,& Wickr me Online.

You can choose your interested products and send inquiry to us.

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7: Which kind of payment do you accept?

 

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8: Package

 

We have standard package, or it can be customized as per your request.

 

 

9: Transportation

 

UPS,TNT,EMS,Fedex,and so on.According to your location, safe customs clearance, generally delivered to your door within7 -15 days in Europe and the United States.



Company Profile Introduction

Xiamen Wonderful Bio Technology Co., Ltd. is a professional company engaged in pharmaceutical and chemical engineering, raw materials, and plant extracts. Our company has long-term cooperation with multiple universities such as the Fujian Academy of Research and the Academy of Medical Sciences. Our company integrates research and development, production, and sales, and has advanced research and development equipment with strong technology. Our company also supports customization of some special products. Our company provides high-quality chemical raw materials, pharmaceutical intermediates, and industrial chemicals to the world. Our products are exported to over 70 countries overseas. Strict quality management system and comprehensive after-sales service. Everything is based on customer satisfaction, and everything is based on the long-term healthy development of the enterprise.

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  • Since: 2023-02-16
  • Address: Room 727, No. 600-3 Nanhai 3rd Road, Xiamen Section, China (Fujian) Pilot Free Trade Zone
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