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Phenacetin Suppliers list
Company Name: Hebei Minshang Biotechnology Co., Ltd
Tel: +86-13582176207
Products Intro: Product Name:Phenacetin
Purity:99% Package:1KG/Tin;1USD
Company Name: Hebei Huanhao Biotechnology Co., Ltd.
Tel: 86-18034554576 whatsapp +8618034554576
Products Intro: Product Name:Phenacetin
Purity:99.7%+ Package:1Kg/Bag;60USD
Company Name: hdzhl biotechnology co., ltd
Tel: 86-13032617415
Products Intro: Product Name:Phenacetin
Purity:0.99 Package:25Kg/Drum;USD
Company Name: Hebei shuoxi biotechnology co. LTD
Tel: +8613081092107
Products Intro: Product Name:phenacetin
Purity:99.8% Package:1KG;60USD
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Products Intro: Product Name:Phenacetin
Purity:USP BP EP Package:1KG;5USD

Lastest Price from Phenacetin manufacturers

  • Phenacetin
  • US $0.00-0.00 / KG
  • 2020-01-07
  • CAS:62-44-2
  • Min. Order: 1mg
  • Purity: 99% HPLC
  • Supply Ability: 2000tons
  • Phenacetin
  • US $100.00 / g
  • 2019-11-28
  • CAS:kf-wang(at)
  • Min. Order: 100g
  • Purity: 99.5%
  • Supply Ability: 100

Related articles

  • The uses of Phenacetin
  • Phenacetin (or acetophenetidin) is a pain-relieving and fever-reducing drug, which was widely used between its introduction in....
  • Aug 27,2019
Phenacetin Basic information
Indications and Usage Mechanisms of Action Side Effects
Product Name:Phenacetin
Synonyms:Shiny phenacetin;phenacetin factory;phenacetin cas 62-44-2 from factory;Phenacetin powder fenacetina 99%;1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4'-ETHOXYACETANILIDE
Product Categories:organic interme-;API-;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs;Organics;Others
Mol File:62-44-2.mol
Phenacetin Structure
Phenacetin Chemical Properties
Melting point 133-136 °C(lit.)
Boiling point 132 °C / 4mmHg
density 1.1248 (rough estimate)
refractive index 1.5710
Fp 2℃
storage temp. 2-8°C
pkapKa 2.2(H2O) (Uncertain);3.5(aqueous acetone) (Uncertain)
form powder
color White
Water Solubility 0.076 g/100 mL
Sensitive Hygroscopic
Merck 14,7204
BRN 1869238
Stability:Stable. Incompatible with strong oxidizing agents, strong acids.
CAS DataBase Reference62-44-2(CAS DataBase Reference)
NIST Chemistry ReferenceAcetamide, N-(4-ethoxyphenyl)-(62-44-2)
EPA Substance Registry SystemPhenacetin (62-44-2)
Safety Information
Hazard Codes T,F
Risk Statements 45-22-20/21/22-36-11
Safety Statements 53-45-36/37-26-16
WGK Germany 3
RTECS AM4375000
HS Code 29251995
Hazardous Substances Data62-44-2(Hazardous Substances Data)
ToxicityLD50 orally in rats: 1.65 g/kg (Boyd)
MSDS Information
4-Acetophenetidine English
ACROS English
SigmaAldrich English
ALFA English
Phenacetin Usage And Synthesis
Indications and UsagePhenacetin is mainly used as an antipyretic analgesic, with slow and lasting effects, treating headaches, neuralgia, joint pain, and fever, and weakly resisting rheumatism and inflammation. Because of toxic side effects and the rapid development of similar drugs, however, it is no longer used alone, only as a raw material in combination with other drugs. Commonly combined with aspirin and caffeine to form a less toxic compound aspirin used to treat the common cold. Can make chlorpheniramine cold tablets by adding a small amount of chlorpheniramine to the above compound, used to treat colds with headache, neuralgia, rheumatism, etc. Can be used as a material for organic synthesis or a pharmaceutical intermediate.
Mechanisms of ActionOn its own, phenacetin has no antipyretic or analgesic effects. In vivo, acetaminophen and paracetamol are metabolized and decomposed to create the antipyretic and analgesic effects. Its decomposites with ammonia and phenyl either not only have no antipyretic and analgesic effects, but also are major factors in its side effects.
Side EffectsLong term use may cause renal papillary necrosis and interstitial nephritis, and even induce renal pelvic cancer and bladder cancer. Phenacetin also makes the hemoglobin to form methemoglobin, decreasing blood oxygen carrying capacity, causing cyanosis. In addition, Phenacetin can cause hemolysis and hemolytic anemia, and is toxic to the retina. Long term use may cause also lead to dependence. Countries including America, Britain, German, and Japan have banned Phenacetin, or required packaging to note that it is “not indicated for long-term usage or large doses.”
Chemical PropertiesAcetophenetidin is a fine, white, crystalline powder or solid. Odorless with a slightly bitter taste
UsesAnalgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.
Usesglycosylation inhibitor
DefinitionChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group.
Brand name[Names previously used: Acetophenetidin; Acetphenetidin.];292-comprimes 369, pulvules 3p bugesic;Acetylosal;Acifein;Acromas;Acropac;Algocratine;Alumidyne;Amypron;Amypylo-n;Angifebrine;Anodin;Antiflu des;Apadine;Apidin;Apracur;Arcin;Asceine;Ascophen;Ascthimindon;Asfeen;Ban-o-pain;Bexophene;Bromo quinina;Butal compound;Butorinal;Calmante muri;Capacetyl;Capramin;Caps dr knapp;Capsula dr. knapp;Ceachin;Cefinal;Cequinyl fort;Chloracet;Citramol;Codopyrin;Codral;Conta-schmerz;Coricidin f;Cotradol;Darvocomp-n;Darvon compuesto 65;Darvon n compuesto;Dentocaps;Dolafort;Dolomo;Doloxene comp forte, capsules;Dolviron;Doregrippin;Doscafis;Doviron;Drinacet;Estrifen;Femcaps;Fenascor;Fenbutal;Flexalgit;Florital;Fonal;Fridol;Friocellin;Funapann;Gripanidan;Harbureta;Hemagene taylor;Icn 65;Influenza tabs;Isollyl;Isomidon;Katagrip;Lekasin;Linarol;Manasul;Mardon;Migesic;Mironal;Monacet;Myolate;Neopyrine;Nevral vit b1 b6;Novacetol;Novosephalgin;Olfano;Omniadol;Papnin;Para-grip;Parametten;Pargesic compound;Pasadex;Pedigel;Phenacetine powder;Phenorial;Polypyrine;Poxy;Procomp-65;Prodigestan;Prodolor;Protension;Quadrochin;Rectoral;Refagan;Repro;Respritin;Rhinazol;Rinurel;Rinutan;Robaxisan-pm;Ron-drive;Rumicine;S antineuralgic;S fc;Sacadol;Sadaspir;Sedalmerck;Sk 65 compound caps.;Soma compound;Soma compuesto;Sonalgin;Spacin;Spasmindon;Spasmo-compralgyl;Synalogos-dc;T h;Tetrex-apc;Tetrracydin;Tiiomapirina;Tomapiena;Triplex;Uga-no;Vandar-65;Vasogesic;Vicks action 500;Zactirin compound-100.
World Health Organization (WHO)Phenacetin, an aniline derivative, was introduced into medicine as an antipyretic over a century ago. It subsequently gained recognition as an analgesic and was available in many proprietary analgesic preparations. However, in the 1940s its habitual use was first implicated as the cause of methaemoglobinaemia and chronic haemolysis. Since 1950 there have been many reports published indicating that abusive use is associated with cumulative renal damage. Evidence also exists to suggest that it may have a carcinogenic potential. The drug has been withdrawn in many countries but may remain available in others. (Reference: (WHODI) WHO Drug Information, 1, 5, 1980)
General DescriptionOdorless fine white crystalline solid with a lightly bitter taste. Used as an analgesic medicine.
Air & Water ReactionsInsoluble in water.
Reactivity ProfilePhenacetin react with oxidizing agents, iodine and nitrating agents.
Fire HazardFlash point data for Phenacetin are not available but Phenacetin is probably combustible.
Safety ProfileConfirmed carcinogen producing tumors of the lildney and bladder. A human poison by an unspecified route. Poison by intravenous and possibly other routes. Moderately toxic by several routes. Human systemic effects by ingestion: cyanosis, liver damage, and methemoglobinemiacarboxyhemo-globinemia. Experimental teratogenic data. Other experimental reproductive effects. Mutation data reported. Chronic effects consist of weight loss, insomnia, shortness of breath, weakness, and often aplastic anemia. When heated to decomposition it emits toxic fumes of NOx,.
Potential ExposurePhenacetin is used as an analgesic and antipyretic drug. It is used alone or in combination with aspirin and caffeine for mild to moderate muscle pain relief. Phenacetin has also been used as a stabilizer for hydrogen peroxide in hair bleaching preparations. A laboratory reagent. In veterinary medicine; it is used as an analgesic and antipyretic.
CarcinogenicityPhenacetin is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
ShippingUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification MethodsCrystallise it from H2O or EtOH, and its solubility in H2O is 0.08% (at ~10o) and 1.2% (at ~100o), and in EtOH it is 6.7% (at ~10o) and 36% (at ~100o). Alternatively it can be purified by solution in cold dilute alkali and re-precipitating by addition of acid to neutralisation point. Dry it in air. [Beilstein 13 H 461, 13 IV 1092.]
IncompatibilitiesOxidizing agents, iodine and nitrating agents.
Waste DisposalIt is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible, return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Permanganate oxidation, microwave plasma treatment, alkaline hydrolysis or incineration.
Phenacetin Preparation Products And Raw materials
Raw materialsAcetic acid glacial-->Acetic anhydride-->4-Acetamidophenol-->Iodoethane-->Phenetidine-->phenylacetic anhydride
Tag:Phenacetin(62-44-2) Related Product Information
2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER N-(4-ETHOXYPHENYL)MALEAMIC ACID Lactyl Phenetidine N-(4-ethoxy-3-nitrophenyl)acetamide Acetoacet-p-phenetidide 4-CHLORO-N-(4-ETHOXYPHENYL)BENZAMIDE Phenacetin Phenetole Sulfanilic acid 4-Aminophenylacetic acid 4-Amino-benzenesulfonic acid monosodium salt 4-Dimethylaminobenzoic acid P-AMINOBENZAMIDE GLUTAMIC ACID Benzocaine o-Phenetidine p-Anisidine Sulfanilamide 4-Aminobenzoic acid