Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Chemical Reagents>Organic reagents>Esters>Ethyl compound>Phenethyl caffeate
Phenethyl caffeate
  • Phenethyl caffeate
  • Phenethyl caffeate

Phenethyl caffeate

Price $10
Package 1kg
Min. Order: 1kg
Supply Ability: 10000
Update Time: 2024-04-28

Product Details

Product Name: Phenethyl caffeate CAS No.: 104594-70-9
Min. Order: 1kg Purity: 99%
Supply Ability: 10000 Release date: 2024/04/28


DescriptionPhenylethyl caffeate is one of the allergens of propolis (bee glue); also contained in poplar-bud secretions.
Chemical PropertiesOff-White Solid
UsesPhenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.
Usesantineoplastic, antiinflammatory, immunomodulator, NFkB blocker
UsesCytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.
Biological ActivityAntioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF- κ B activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.
Biochem/physiol ActionsCAPE exhibits several properties such as anticarcinogenic, immunomodulatory activities, antioxidant, antiviral, anti-inflammatory, hypoglycaemic effect, cardioprotective and inhibits gastric secretion. It also has an inhibitory effect on fibroblasts growth factor type 2 (FGF-2), a tumor growth factor in breast cancer.
Contact allergensCapee is one of the allergens of propolis (bee glue). It is also contained in poplar bud secretions.
Anticancer ResearchCaffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is a natural phenolcompound and an active component of propolis from honeybee hives. Torkiet al. (2017)investigated the effect of phosphatidylinositol 3-kinase/AKT/mammaliantarget of rapamycin (PI3K/Akt/mTOR) signaling pathway dual inhibitor, NVP-BEZ235,and CAPE on TNBC cell line (MDA-MB-231), stimulated withtransforming growth factor (TGF)-β1 for 14 days. CAPE in combination with NVP-BEZ235synergistically inhibited cell growth and reduced CXCR4 expression.Also, treatment of MDA-MB-231 cells with CAPE and NVP-BEZ235 time-dependentlyinhibited the expression of p-Forkhead Box O3a (FOXO3a). In a nutshell,these results indicate that tumour metastasis and progression in TNBC cellscan be effectively reduced through the concurrent use of NVP-BEZ235 and CAPE(Torki et al. 2017).

If you want to know more, email to: sales18@staherb.cn or call us:+86 13548561509 or send online message. Staherb is pleased to serve you.

Company Profile Introduction

Changsha Staherb Natural Ingredients Co., Ltd., a good supplier of professional herb extracts, especially those with high purity and standardized production process. Our company devotes to supply high quality products and services to customers in R&D and production fields of health products, cosmetics, feed additives and biopesticides. With cordial and professional R&D, sales and after-sales service groups, Staherb has potent capabilities both in R&D and production. The company persists in high investment on R&D of active ingredients of plants and promotes innovation on demands of customers. Upon constant R&D and tracing of new technologies and new products, Staherb makes effective cooperation with famous research institutes, such as CAS Kunming Institute of Botany, State Key Lab of Hunan Forest Products and Chemical Engineering, Hunan Agricultural University and so on. Now the main products of Staherb are standardized high purity plant extracts, including Epimedium (10-98%), Euccomia Bark Extract (5-95%), Amygdalin (50-98%), Ursolic acid (25-98%) and Corosolic acid (1-98%). In order to meet customers’ research needs, our company also provides over 600 plant extracts, most of which are high-purity monomer plant compounds and reference substance. And some products can be supplied with milligram-scale, kilogram-scale or even to ton-scale. In addition, based upon the powerful R&D capability, Staherb can provide both products customization services and R&D outsourcing services according to customers’ specific requirements, so that to meet their continual innovation needs in the fields of natural products’ discovery and production. Staherb endeavors to accelerate the response rate of supply chain as well as improve the service superiority upon customers’ continual innovation needs. It also devotions to establish good partnerships with customers and to construct a safe development model which is forward-looking, reciprocal and coexisting, thus to cre

You may like

Recommended supplier

Product name Price   Suppliers Update time
$30.00/1KG
VIP1Y
Henan Fengda Chemical Co., Ltd
2024-04-26
$1.00/1kg
Hubei Langyou International Trading Co., Ltd
2023-10-23
$0.00/25KG
VIP4Y
Hebei Mojin Biotechnology Co., Ltd
2023-09-14
$100.00/1kg
VIP1Y
Henan Bao Enluo International TradeCo.,LTD
2023-08-04
$8.00/1G
Hebei Ningnan Trade Co. LTD
2022-11-04
$0.00/1kg
VIP2Y
Wuhan Senwayer Century Chemical Co.,Ltd
2022-10-17
$0.00/25kg
PNP Biotech Co. Ltd
2022-09-16
$100.00/1kg
VIP2Y
Hebei Duling International Trade Co. LTD
2022-09-01
$200.00/10g
Wuhan Qiami Technology Co., Ltd
2022-07-30
$90.00/1KG
Hebei baicao biology science and technology co., ltd
2022-05-06
  • Since: 2010-04-06
  • Address: No. 186, Lugu Valley Garden Road, High-tech Dev. Zone, Changsha, Hunan, China
INQUIRY
戴杏花
+86-18374838656
info@staherb.cn