PHPS1 NEW

Price	$89	$139	$297
Package	5mg	10mg	25mg

Min. Order:
Supply Ability:	10g
Update Time:	2025-04-27

Product Details

Product Name: PHPS1	CAS No.: 314291-83-3
Purity: 99.77%	Supply Ability: 10g
Release date: 2025/04/27

Product Introduction

Bioactivity

Name	PHPS1
Description	PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.
In vitro	PHPS1 (30 μM; 6 days) inhibits human tumor cell proliferation, and at concentrations of 5-20 μM (5-360 minutes), it inhibits Erk1/2 phosphorylation in a dose-dependent manner without affecting Akt and Stat3 phosphorylation[1].
In vivo	PHPS1 (3 mg/kg; i.p. injection; administered daily during the final week of a high-fat diet) reduces susceptibility to atherosclerosis in Ldlr-/- mice[2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 16.25 mg/mL (34.91 mM), Sonication is recommended.
Keywords	SHP-2 \| Shp2 \| Shp-1 \| Shp1 \| PTP1B \| prostate \| PHPS1 \| Phosphatase \| lung \| kidney \| Inhibitor \| inhibit \| Erk1/2 \| colon \| carcinoma \| cancer \| atherosclerosis
Inhibitors Related	PTP1B-IN-22 \| Disodium monofluorophosphate \| β-Glycerophosphate disodium salt pentahydrate \| Idoxuridine \| Tartaric acid disodium dihydrate \| Cyclosporine \| Stearic acid \| Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride \| CaMKP Inhibitor \| L-Ascorbic acid 2-phosphate magnesium \| Cyclosporin A \| Trimyristin
Related Compound Libraries	Glycometabolism Compound Library \| Bioactive Compound Library \| Hematonosis Compound Library \| Inhibitor Library \| Metabolism Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Compound Library \| Phosphatase Inhibitor Library \| Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

Recommended supplier

Product name	Price		Suppliers	Update time
PHPS1 Sodium	$931.00/25mg	VIP1Y	TargetMol Chemicals Inc.	2024-11-19

TargetMol Chemicals Inc.

5YR

United States

Since: 2011-01-07
Address: 36 Washington Street, Wellesley Hill, MA

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