SGK1-IN-1 NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-09-30 |
Product Details
| Product Name: SGK1-IN-1 | CAS No.: 1279829-87-6 |
| Supply Ability: 10g | Release date: 2025/09/30 |
Product Introduction
Bioactivity
| Name | SGK1-IN-1 |
| Description | SGK1-IN-1 (compound 14n) is a highly potent SGK1 (Serum/Glucocorticoid Regulated Kinase 1) inhibitor, with inhibitory activities of 41 nm, 128 nm, and 310 nm against hSGK1/2/3 at 500 μM ATP, respectively, and can be used for studying SGK1-related cancers and metabolic diseases. |
| In vitro | Method: Kinase inhibition assays were conducted to evaluate the selectivity and activity of SGK1-IN-1 (14n) against SGK family members at different ATP concentrations. Additionally, its inhibitory effect on GSK3β phosphorylation was assessed in U2OS cells. Result: SGK1-IN-1 showed strong activity against hSGK1 (IC₅₀ = 1 nM), good activity against hSGK2, moderate activity against hSGK3 (IC₅₀ = 41 nM), and exhibited cellular activity with an IC₅₀ of 0.69 μM in U2OS cells.[1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 1.5 mg/mL (3.58 mM), when pH is adjusted to 12 with 1M NaOH. DMSO : 40 mg/mL (95.5 mM), Sonication is recommended. |
| Keywords | SGK1-IN-1 | SGK-1-IN-1 | SGK1IN1 | SGK1 IN 1 | SGK-1 |
| Inhibitors Related | BN201 | AT13148 | URMC-099 | GSK 650394 | Ro-3306 | EMD638683 R-Form | EMD638683 | SGK1-IN-4 | SI-113 | PROTAC SGK3 degrader-1 | CKI-7 | BRD7389 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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