SK1-I hydrochloride NEW
| Price | $332 |
| Package | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: SK1-I hydrochloride | CAS No.: 2366222-05-9 |
| Purity: 99.80% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | SK1-I hydrochloride |
| Description | SK1-I hydrochloride is the salt form of SK1-I(BML-258). SK1-I is a selective and competitive sphingosine kinase 1 (SphK1) inhibitor and sphingosine analog that is inactive against SphK2 and a variety of other protein kinases, and possesses anti-leukemic potential to inhibit tumor cell growth and promote apoptosis. |
| In vitro | The effect of SK1-I hydrochloride on cancer cell growth, survival, and apoptosis is closely related to the TP53 status. Treatment of HCT116 cells with a defective TP53 mutation and normal HCT116 cells with SK1-I hydrochloride (0-10μM) for 24 hours revealed that the growth and survival rate of normal HCT116 cells decreased significantly. In protein blot analysis, after treating both cell types with SK1-I hydrochloride (0-20μM) for 12 hours, it was found that CASP3 cleavage was increased in normal HCT116 cells, making them more prone to apoptosis [1]. |
| In vivo | In the C57BL/6 male mouse model, pretreatment with SK1-I hydrochloride (intraperitoneal injection, 75mg/kg, a single dose administered 24 hours before baseline mean arterial pressure measurement) showed a significant hypotensive effect, significantly reducing the baseline mean arterial pressure (MAP) [2]. |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Fingolimod hydrochloride | SLP9101555 | BMS-960 | LX-2931 | Sphingosine-1-phosphate | CYM50374 | ASP-4058 | Ceranib-2 | Siponimod | Fingolimod | MP-A08 | Ozanimod |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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