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Postion:Product Catalog >API>Circulatory system drugs>Lipid regulating drugs>Vildagliptin
Vildagliptin
  • Vildagliptin
  • Vildagliptin
  • Vildagliptin
  • Vildagliptin
  • Vildagliptin

Vildagliptin

Price Get Latest Price
Package 1Kg/Bag 25Kg/Bag 100Kg/Bag
Min. Order: 1Kg/Bag
Supply Ability: 20 tons
Update Time: 2024-04-22

Product Details

Product Name: Vildagliptin CAS No.: 274901-16-5
EC-No.: 630-410-0 Min. Order: 1Kg/Bag
Purity: 99% up, High Density Supply Ability: 20 tons
Release date: 2024/04/22

Product Information


Product name

Vildagliptin

CAS No.

274901-16-5

Molecular Formula

C17H25N3O2

Molecular Weight

303.404

Quality Standard

99% up by HPLC

Appearance

White or whitish solid powder


COA of Vildagliptin


ITEMS

SPECIFICATION

RESULT

Appearance

White or whitish solid powder

White solid powder



Identity

High-performance liquid chromatograph HPLC:

The retention time of test sample major peak complies to reference standard


Almost the same

IR Infrared spectrometry:

The IR spectrum of test sample should comply to reference standard


Almost the same

Melting point

148.0 C - 152.0C

148.6.0C-149.1C

Loss on drying

 1.0%

0.36%

Residual on ignition

 0.1%

0.04%

Related substance

Any single impurity  0.1%

Total impurities  1.0%

Conforms

0.65%

Heavy metals

 20 ppm

< 10 ppm

Assay

99.0% - 102.0%

99.19%

Conclusion

The sample complies with the above specification

Usage

Vildagliptin is a selective, competitive and reversible DPP24 inhibitor. Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like polypeptide 1 (GLP-1) are important hormones to maintain glucose concentration in the body, and both have incretin effects. The insulin-stimulating effect of GIP in patients with type 2 diabetes is impaired, and only GLP-1 can play the role of insulin-stimulating hormone secretion. GLP-1 also inhibits glucagon secretion and suppresses gastric emptying to increase satiety (suppression of appetite). DPP24 binds to proteins and exists in many tissues, such as kidney, liver, brush border of small intestinal membrane, pancreatic duct, lymphocytes, endothelial cells, and it can rapidly degrade GLP-1 by hydrolyzing the N-terminal 2 alanine of GLP-1. inactivated. This product inhibits the activity of this enzyme by combining with DPP24 to form a DPP24 complex. It increases the concentration of GLP-1 and promotes the production of insulin by islet β cells, while reducing the concentration of glucagon, thereby reducing blood sugar. and had no significant effect on body weight.


Vildagliptin can reduce fasting and postprandial blood glucose levels, postprandial glucagon secretion and improve B cell function, providing a new option for the treatment of type 2 diabetes patients. Safety and effectiveness of this medicine in combination with other medicines.

Article illustration

Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

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