Xylometazoline hydrochloride NEW
| Price | $50 | $1 |
| Package | 1KG | 1000KG |
| Min. Order: | 1KG |
| Supply Ability: | g-kg-tons, free sample is available |
| Update Time: | 2023-12-23 |
Product Details
| Product Name: Xylometazoline hydrochloride | CAS No.: 1218-35-5 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: g-kg-tons, free sample is available | Release date: 2023/12/23 |
| Lead time: In stock | Packaging: bottle/drum/bucket/IBC, as request. |
| Delivery: By sea, by air, by express | Origin: Manufacturer |
1. Product information
| Product Name: | Xylometazoline hydrochloride |
| Synonyms: | 2-(4-tert-butyl-2,6-dimethylbenzyl)-2-imidazolinmonohydrochloride;2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1h-imidazol;Galazolin;Neo-Rinoleina;Neo-Synephrine II;Novorin;Olynth;Therapin |
| CAS: | 1218-35-5 |
| MF: | C16H25ClN2 |
| MW: | 280.84 |
| EINECS: | 214-936-4 |
| Product Categories: | API;ALBENZA;Miscellaneous Natural Products;Adrenoceptor;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 1218-35-5.mol |
 | |
| Xylometazoline hydrochloride Chemical Properties |
| Melting point | 131-133 C |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, in ethanol (96 per cent) and in methanol. |
| form | neat |
| color | Crystals |
| Merck | 14,10086 |
| CAS DataBase Reference | 1218-35-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, monohydrochloride (1218-35-5) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 36-26 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | NJ2390000 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29332900 |
| Toxicity | LD50 orl-rat: 230 mg/kg KSRNAM 5,555,71 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| Xylometazoline hydrochloride Usage And Synthesis |
| Chemical Properties | Xylometazoline hydrochloride is white or almost white, crystalline powder. |
| Originator | Otrivin,Geigy,US,1959 |
| Uses | Xylometazoline hydrochloride may be used as a reference standard in determining the xylometazoline hydrochloride content in samples of nasal drops using high performance liquid chromatography (HPLC). |
| Uses | Xylometazoline hydrochloride is used as a nasal decongestant. |
| Uses | anthelmintic |
| Manufacturing Process | 62 grams of para-tertiany-butyl-ortho,ortho'-dimethyl-phenyl-acetonitrile [obtainable, for example, by the method of Buu-Hoi and P. Cagniant, Bulletin de la Societe Chimique de France, volume 9, page 891 (1942)], 20.6 grams of ethylenediamine of 96% purity and 1.55 cc of carbon disulfide are heated together in a distillation flask with the exclusion of moisture for 48 hours on a boiling water bath. Ammonia is evolved. Upon cooling the reaction product solidifies and is then dissolved in benzene, the solution is filtered while hot with the addition of animal charcoal and petroleum ether is added. The mixture is filtered to remove the impurities that are first precipitated and by the further addition of petroleum ether 2-(para-tertiary-butyl-ortho,ortho'- dimethyl-phenyl-methyl)-imidazoline is caused to crystallize out. The product melts at 131° to 133°C after being recrystallized from a mixture of benzene and petroleum ether. It can be converted into its hydrochloride as follows: 189 grams of 2-(para-tertiary-butyl-ortho,ortho'-dimethyl-phenyl-methyl)- imidazoline are dissolved in 400 cc of absolute ethanol, the solution is rendered acid by the addition of 104 cc of an ethanolic solution of hydrochloric acid of 30% strength, the mixture is filtered with the addition of animal charcoal, and dry ethyl acetate and absolute ether are added until crystallization sets in. After cooling the mixture, the salt is filtered off with suction and crystallized several times from absolute ethanol with the use of animal charcoal and the addition of dry mixture of ethyl acetate and ether. The hydrochloride so obtained melts at 327° to 329°C (with decomposition). |
| Brand name | Neo-Synephrine II (Sterling Winthrop); Otrivin Hydrochloride (Ciba-Geigy). |
| Therapeutic Function | Adrenergic (vasopressor) |
| General Description | Xylometazoline hydrochloride is a derivative of imidazole, and a representative of the class of α1 agonists. It is commonly used in nasal decongestants, which works on the principle of constricting the blood vessels in the mucous membranes. |
| Biochem/physiol Actions | α-adrenoceptor agonist; imidazoline binding site ligand. |
| Safety Profile | Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and HCl. |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
For more details, pls contact us freely.
Email address : elin@fdachem.com
Mob: 86 13613820652
WhatsApp/Skype/Wechat/LINE: 86 13613820652
Company Profile Introduction
Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.
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- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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