ChemicalBook >>Aminopterin>>N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid(54-62-6)

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid(54-62-6)

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid(54-62-6)
Product IdentificationBack to Contents
【Product Name】

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
【Synonyms】

4-Aminofolic acid
4-Aminopteroylglutamic acid
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-
【CAS】

54-62-6
【Formula】

C19H20N8O5
【Molecular Weight】

440.42
【EINECS】

200-209-9
【RTECS】

MA1050000
【RTECS Class】

Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
【Merck】

12,493
【Beilstein/Gmelin】

69045
【Beilstein Reference】

4-26-00-03831
Physical and Chemical PropertiesBack to Contents
【Appearance】

Clusters of yellow needles.
【Melting Point】

260-265
【pKa/pKb】

3.52 (pKa)
【Partition Coefficient】

.15
【Usage】

Is a folic acid antagonist.
First Aid MeasuresBack to Contents
【Ingestion】

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
【Inhalation】

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
【Skin】

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
【Eyes】

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
Handling and StorageBack to Contents
【Storage】

Cool dry location in a tightly sealed container. Avoid exposure to light.
【Handling】

Do not breath dust, get in eyes, on skin or on clothing. Avoid prolonged or repeated exposure. Always work in a chemical hood and while using the recommended protective equipment.
Hazards IdentificationBack to Contents
【Inhalation】

May be fatal if inhaled, ingested or absorbed through the skin. Causes irritation.
【Skin】

See inhalation.
【Eyes】

See inhalation
【Ingestion】

See inhalation.
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
【Respirators】

NIOSH/MSHA approved respirator.
【Exposure Effects】

Chronic exposure may cause congenitial malformations of the fetus. Studies havs shown mutagenic effects. Causes blood effects.
【Poison Class】

1*
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal.
Stability and ReactivityBack to Contents
【Stability】

Stable at normal temperatures and pressures.
【Incompatibilities】

Strong oxidizing agents.
【Decomposition】

Oxides of carbon and nitrogen.
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