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54-62-6

54-62-6 Structure

54-62-6 Structure
IdentificationMore
[Name]

Aminopterin
[CAS]

54-62-6
[Synonyms]

4-AMINOFOLIC ACID
4-AMINO-PGA
4-AMINOPTEROYLGLUTAMIC ACID
4-AMINOPTEROYL-L-GLUTAMIC ACID
AMINOPTERIN
AMINOPTERINE
4-amino-4-deoxypteroylglutamate
4-amino-folicaci
4-aminofolicacid[qr]
4-amino-pga[qr]
4-aminopteroylglutamicacid[qr]
4-diamino-6-pteridinyl)methyl)amino)benzoyl)-n-(p-(((l-glutamicaci
AGPA
ai3-26079[qr]
aminopteridine
aminopterinum
aminopterinum[qr]
a-ninopterin
apga
apga[qr]
[EINECS(EC#)]

200-209-9
[Molecular Formula]

C19H20N8O5
[MDL Number]

MFCD00036692
[Molecular Weight]

440.41
[MOL File]

54-62-6.mol
Chemical PropertiesBack Directory
[Appearance]

Aminopterin is a white to yellow powder; commonly used as the dihydrate which forms clustersof yellow needles
[mp ]

228-235 °C (dec.)
[alpha ]

18 º (c=1% in 0.1N NaOH)
[storage temp. ]

2-8°C
[solubility ]

2 M NaOH: 50 mg/mL
[form ]

powder
[color ]

yellow
[Usage]

A folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase a
[Merck ]

13,471
[CAS DataBase Reference]

54-62-6(CAS DataBase Reference)
[EPA Substance Registry System]

54-62-6(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

T+
[Risk Statements ]

R61:May cause harm to the unborn child.
R28:Very Toxic if swallowed.
R63:Possible risk of harm to the unborn child.
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed .
[Safety Statements ]

S53:Avoid exposure-obtain special instruction before use .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S22:Do not breathe dust .
[RIDADR ]

UN 2811 6.1/PG 1
[WGK Germany ]

3
[RTECS ]

MA1050000
[F ]

8-10-23
[HazardClass ]

6.1(a)
[PackingGroup ]

I
[HS Code ]

29339900
[Safety Profile]

Poison by ingestion and intraperitoneal routes. Human and experimental teratogenic data. Other experimental reproductive effects. Mutation data reported. Human systemic effects by ingestion: gastrointestinal. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx,.
[Hazardous Substances Data]

54-62-6(Hazardous Substances Data)
Hazard InformationBack Directory
[General Description]

Clusters of yellow needles. Used as a rodenticide, medicine and rodenticide. Not registered as a rodenticide in the U.S.
[Health Hazard]

An antimetabolite; antagonizes the utilization of folic acid by the body. Highly toxic by ingestion.
[Potential Exposure]

Aminopterin is used as a medicine (as a folic acid antagonist), rodenticide, and agricultural chemical.
[First aid]

Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
[Shipping]

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required
[Waste Disposal]

It is inappropriate and possibly dangerous to the environment to dispose of expired or wastepharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid(54-62-6).msds
Spectrum DetailBack Directory
[Spectrum Detail]

Aminopterin(54-62-6)IR2
Aminopterin(54-62-6)MS
Aminopterin(54-62-6)IR1
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

54-62-6(sigmaaldrich)
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