标题：Anti-Human TSHR/LGR3 Antibody (K1-70)抗体,AntibodySystem Laboratories
链接：https://www.antibodysystem.com/product/7264.html
名称：Anti-Human TSHR/LGR3 Antibody (K1-70)抗体
别名：Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3, RHD18102
货号：FHD18120
宿主：Mouse
适用物种：Human
存储缓冲区：0.01M PBS, pH 7.4.
形式：Liquid
纯度：>95%
克隆：Monoclonal
同型：IgG2a, lambda
应用：Block, ELISA, FCM
内毒素水平：Please contact with the lab for this information.
UniProt：P16473
用途范围：仅用于科研
储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
产品购买联系方式：027-65279366 /18162686757
邮箱：biolab-reagents@atagenix.com
QQ：2663991332
参考文献：
A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves' orbitopathy. PMID: 36742308
Mechanisms of Action of TSHR Autoantibodies. PMID: 26361260
Modulation of TSHR signaling by posttranslational modifications. PMID: 17524661
Central Tolerance Mechanisms to TSHR in Graves' Disease: Contributions to Understand the Genetic Association. PMID: 30396220
TSHR-based chimeric antigen receptor T cell specifically deplete auto-reactive B lymphocytes for treatment of autoimmune thyroid disease. PMID: 37690235
Controversial constitutive TSHR activity: patients, physiology, and in vitro characterization. PMID: 24845969
Genetics of Graves' Disease: Special Focus on the Role of TSHR Gene. PMID: 26361261
Presence of TSHR in NK Cells and Action of TSH on NK Cells. PMID: 34392245
Signaling Dynamics of TSHR-Specific CAR-T Cells Revealed by FRET-Based Biosensors. PMID: 35252208
Variant of TSHR is Not a Frequent Cause of Congenital Hypothyroidism in Chinese Han Patients. PMID: 34377013
Association between TSHR gene methylation and papillary thyroid cancer: a meta-analysis. PMID: 32279226
LGR4: A New Receptor Member in Endocrine and Metabolic Diseases. PMID: 36791020
The biology and evolution of the Dilp8-Lgr3 pathway: A relaxin-like pathway coupling tissue growth and developmental timing control. PMID: 29715504
Sex-specific regulation of Lgr3 in Drosophila neurons. PMID: 26884206
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain. PMID: 33558728
Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability. PMID: 26441350
Mating activates neuroendocrine pathways signaling hunger in Drosophila females. PMID: 37184218
[Some insulins to orchestrate growth]. PMID: 28990566
Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing. PMID: 26510564
The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction. PMID: 34099654
A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3. PMID: 26429885
Systemic signalling and local effectors in developmental stability, body symmetry, and size. PMID: 31225459
Growth Coordination During Drosophila melanogaster Imaginal Disc Regeneration Is Mediated by Signaling Through the Relaxin Receptor Lgr3 in the Prothoracic Gland. PMID: 27558136
Drosophila Insulin-Like Peptide 8 (DILP8) in Ovarian Follicle Cells Regulates Ovulation and Metabolism. PMID: 32849266
TSH receptor specific monoclonal autoantibody K1-70(TM) targeting of the TSH receptor in subjects with Graves' disease and Graves' orbitopathy-Results from a phase I clinical trial. PMID: 35088429
Hormone- and antibody-mediated activation of the thyrotropin receptor. PMID: 35940204
Structure of full-length TSH receptor in complex with antibody K1-70. PMID: 36069797
Mechanisms of Action of TSHR Autoantibodies. PMID: 26361260
Blocking type TSH receptor antibodies. PMID: 26000138
Blocking the Thyrotropin Receptor with K1-70 in a Patient with Follicular Thyroid Cancer, Graves' Disease, and Graves' Ophthalmopathy. PMID: 34114495
Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70(TM) a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity. PMID: 32257067
In vivo effects of a human thyroid-stimulating monoclonal autoantibody (M22) and a human thyroid-blocking autoantibody (K1-70). PMID: 26000124
Management of Graves' hyperthyroidism: present and future. PMID: 35287535
Investigational drugs in early stage clinical trials for thyrotoxicosis with hyperthyroidism. PMID: 30354697
Monoclonal Antibodies for the Treatment of Graves Orbitopathy: Precision Medicine? PMID: 36727923
Analytical Performance and Validation of a Bioassay for Thyroid-Blocking Antibodies. PMID: 26956921
Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody. PMID: 21247981
Similarities and differences in interactions of thyroid stimulating and blocking autoantibodies with the TSH receptor. PMID: 22829655
CAR-T Cells Targeting TSHR Demonstrate Safety and Potent Preclinical Activity Against Differentiated Thyroid Cancer. PMID: 34751400
Glycosylation pattern analysis of glycoprotein hormones and their receptors. PMID: 27875255
Performance and Specificity of 6 Immunoassays for TSH Receptor Antibodies: A Multicenter Study. PMID: 29071236
TSH receptor - autoantibody interactions. PMID: 19530271
Inhibition of TSH/IGF-1 Receptor Crosstalk by Teprotumumab as a Treatment Modality of Thyroid Eye Disease. PMID: 34788857
A rapid homogenous bioassay for detection of thyroid-stimulating antibodies based on a luminescent cyclic AMP biosensor. PMID: 34871593
Novel Approaches for Immunosuppression in Graves' Hyperthyroidism and Associated Orbitopathy. PMID: 33511082
Experimental Reproduction of Dynamic Fluctuation of TSH Receptor-Binding Antibodies Between Stimulation and Inhibition. PMID: 31745531
Crystal structure of a ligand-free stable TSH receptor leucine-rich repeat domain. PMID: 30689545
Monoclonal autoantibodies to the TSH receptor, one with stimulating activity and one with blocking activity, obtained from the same blood sample. PMID: 20550534
Thyroid stimulating hormone exhibits the impact on LDLR/LDL-c via up-regulating hepatic PCSK9 expression. PMID: 28987238
Hypothalamic-pituitary-thyroid axis hormones stimulate mitochondrial function and biogenesis in human hair follicles. PMID: 23949722
A novel bioassay for anti-thyrotrophin receptor autoantibodies detects both thyroid-blocking and stimulating activity. PMID: 23647395
PDGF enhances orbital fibroblast responses to TSHR stimulating autoantibodies in Graves' ophthalmopathy patients. PMID: 22438231
Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structure. PMID: 21834684