中文名：厄达替尼（JNJ-42756493）
英文名：Erdafitinib (JNJ-42756493)
纯度：Moligand™，≥97.5%
货号：E414001
Cas号：1346242-81-6
存储温度：-20°C储存,充氩
运输条件：超低温运输
产品介绍：
Information
Erdafitinib (JNJ-42756493) is a potent and selective orally bioavailable, panfibroblast growth factor receptor (FGFR)inhibitor with potential antineoplastic activity. Erdafitinib also binds toRET (c-RET),CSF-1R,PDGFR-α/PDGFR-β,FLT4,Kit (c-Kit)andVEGFR-2and induces cellularapoptosis.
Targets
FGFR ; RET ; CSF-1R ; PDGFR ; Kit 16439,
In vitro
JNJ-42756493 is a potent, oral pan-FGFR tyrosine kinase inhibitor with half-maximal inhibitory concentration values in the low nanomolar range for all members of the FGFR family (FGFR1 to FGFR4), with minimal activity on vascular endothelial growth factor receptor (VEGFR) kinases compared with FGFR kinases (approximately 20-fold potency difference). the proliferation of cells treated with JNJ-42756493 is decreased, associated with increased apoptotic death and decreased cell survival.
In vivo
growth of NCI-H716 tumors is delayed by 5 days by drug treatment alone, although when drug delivery is stopped the relative tumor volume increased compared to control. JNJ-42756493 shows favorable drug like properties and displays a high distribution to lung, liver and kidney tissue. JNJ-42756493 is well tolerated at efficacious doses and results in potent dose-dependent antitumor activity accompanied by pharmacodynamic modulation of tumor FGFR and downstream pathway components.
Cell Research(from reference)
Cell lines：HCT116, HCA7, Caco2 and NCI-H716 cells
Incubation Time：72 h
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/E414001.html
关键字： AS-35040 ; Erdafitinib(JNJ-42756493) ; NCGC00475735-01 ; BCP20346
上海阿拉丁生化科技股份有限公司是A股上市公司（（股票代码：688179），专注于科研试剂的研发、生产和销售，已陆续建立多个工厂和研发中心。作为领军企业，阿拉丁始终坚持质量第一，连续13年被评为“最受欢迎试剂品牌”。
阿拉丁目前常备库存试剂产品品种超过7万种，SKU总数超过46万，产品线涵盖了化学试剂、生化试剂、药靶配体、蛋白质和抗体等多个领域，是国内少数化学试剂到生物试剂全面发展的国产试剂品牌，产品同步发布在我们国内外电商平台。