A New and Practical Synthesis of Vortioxetine Hydrobromide
Published:13 April 2015
DOI: 10.1055/S-0034-1380505
Abstract
Abstract A new and improved synthetic route to vortioxetine hydrobromide is established on a hectogram scale through three simple steps in 63% yield and with 99% purity (HPLC). The key step is the cyclization of the piperazine ring in the final step. Purification methods for the intermediates involved in the route are given.