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iScience

iScience

IF:4.6 CiteScore:7.2 Articles:1972
Science has many big remaining questions. To address them, we will need to work collaboratively and across disciplines. The goal of iScience is to help fuel that type of interdisciplinary thinking. iScience is a new open-access journal from Cell Press that provides a platform for original research in the life, physical, and earth sciences. The primary criterion for publication in iScience is a significant contribution to a relevant field combined with robust results and underlying methodology. The advances appearing in iScience include both fundamental and applied investigations across this interdisciplinary range of topic areas. To support transparency in scientific investigation, we are happy to consider replication studies and papers that describe negative results. We know you want your work to be published quickly and to be widely visible within your community and beyond. With the strong international reputation of Cell Press behind it, publication in iScience will help your work garner the attention and recognition it merits. Like all Cell Press journals, iScience prioritizes rapid publication. Our editorial team pays special attention to high-quality author service and to efficient, clear-cut decisions based on the information available within the manuscript. iScience taps into the expertise across Cell Press journals and selected partners to inform our editorial decisions and help publish your science in a timely and seamless way.

Identification of antimalarial drugs and bradykinin as ligands of the Plasmodium membrane protein PfSR10

Published: 21 October 2025 DOI: 10.1016/j.isci.2025.113807
Dan Jiang, Xin Wen, Ji-Fei Han, Qiu-Xia Cheng, Ru Zhang, Yuan Zheng, Kai Zheng, Shao-Hui Huang, Jia-Yuan Chen, Su-Wen Li, Zhi-Shuai Yang, Bing Han, Lu Tie, Fan Yang, Peng-Ju Zhang, Peng Xiao, Hui Lin, Xiao Yu, Jin-Peng Sun

LncRNA AC021683.2 promotes chemotherapy resistance in acute myeloid Leukemia

Published: 26 August 2025 DOI: 10.1016/j.isci.2025.113439
Lan Li, Xue-Ni An, Yong-Tong Ruan, Xin Liang, Jing-Lan Hao, Guang-Xun Gao, Jun-Fang Bi, Yan-Rong Gao, Xiao Lu, Hai-Long Tang, Ping Gao, Xiao-Ming Dong

Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma

Published: 3 July 2025 DOI: 10.1016/j.isci.2025.113053
Shun Deng , Rilin Deng , Jinfeng Wang , Qi Hu , Biaoming Xu , Jinhai Zheng , Mingjing Peng , Wenzhi Tan , Haizhen Zhu , Chaohui Zuo

The maternal vGluT2 and embryonic mGluR3 signaling relay system controls offspring wing dimorphism in pea aphid

Published: 6 May 2025 DOI: 10.1016/j.isci.2025.112591
Yiyang Yuan , Yanyan Wang , Wanwan Ye , Liqiang Xie , Erliang Yuan , Huijuan Guo , Shifan Wang , Fang Dong , Keyan Zhu-Salzman , Feng Ge , Yucheng Sun

GPX4 dependent ferroptosis sensitivity is a fitness trade-off for cell enlargement

Published: 9 April 2025 DOI: 10.1016/j.isci.2025.112363
Kuan Yoow Chan , Yini Yu , Yidi Kong , Ling Cheng , Renzhi Yao , Phoebe Sha Yin Chair , Ping Wang , Rong Wang , Wan-Yang Sun , Rong-Rong He , Junxia Min , Fudi Wang , Mikael Björklund

Tracing specificity of immune landscape remodeling associated with distinct anticancer treatments

Published: 20 February 2025 DOI: 10.1016/j.isci.2025.112071
Floriane Cannet, Célia Sequera, Paula Michea Veloso, Abdessamad El Kaoutari, Melissa Methia, Sylvie Richelme, Muge Kaya, Afef Cherni, Mathieu Dupont, Jean-Paul Borg, Christian Morel, Yannick Boursier, Flavio Maina

Stiff extracellular matrix activates the transcription factor ATF5 to promote proliferation of cancer cells

Published: 17 February 2025 DOI: 10.1016/j.isci.2025.112057
Seiichiro Ishihara, Atsushi Enomoto, Akihiro Sakai, Tadashi Iida, Shoichiro Tange, Noriyuki Kioka, Akihiro Nukuda, Ayaka Ichikawa Nagasato, Motoaki Yasuda, Takashi Tokino, Hisashi Haga

Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality

Published: 13 February 2025 DOI: 10.1016/j.isci.2025.112025
Xiang-Le Zhang , Hong-Wei Yue , Ya-Jun Liu , Jian-Yang Wang , Heng-Tong Duan , Yin-Hu Liu , Lei-Lei Jiang , Hong-Yu Hu

Imaging flow cytometry reveals divergent mitochondrial phenotypes in mitochondrial disease patients

Published: 17 January 2025 DOI: 10.1016/j.isci.2024.111496
Irena.J.J. Muffels , Richard Rodenburg , Hanneke L.D. Willemen , Désirée van Haaften-Visser , Hans Waterham , Niels Eijkelkamp , Sabine A. Fuchs , Peter M. van Hasselt

Penfluridol targets septin7 to suppress endometrial cancer by septin7-Orai/IP3R-Ca 2+ -PIK3CA pathway

Published: 19 December 2024 DOI: 10.1016/j.isci.2024.111640
Lingyi Song, Huiwen Wu, Xiao Sun, Xiaohu Liu, Xianwu Ling, Wei Ni, Lijuan Li, Beibei Liu, Jinlian Wei, Xiaokang Li, Jian Li, Yudong Wang, Fei Mao

Elucidating the linagliptin and fibroblast activation protein binding mechanism through molecular dynamics and binding free energy analysis

Published: 13 November 2024 DOI: 10.1016/j.isci.2024.111368
Mingsong Shi, Fang Wang, Zhou Lu, Yuan Yin, Xueting Zheng, Decai Wang, Xianfu Cai, Meng Jing, Jianjun Wang, Junxian Chen, Xile Jiang, Wenliang Yu, Xiaoan Li

SART1 modulates poly-(ADP-ribose) chain accumulation and PARP1 chromatin localization

Published: 24 October 2024 DOI: 10.1016/j.isci.2024.111252
Samuele Lodovichi, Thales C Nepomuceno, Nicholas T Woods, Uwe Rix, John M Koomen, Achille Pellicioli, Alvaro Galli, Alvaro N A Monteiro

Selenium supplementation elevated SELENBP1 to inhibit fibroblast activation in pulmonary arterial hypertension

Published: 26 September 2024 DOI: 10.1016/j.isci.2024.111036
Benhui Liang, Wenchao Lin, Yiyang Tang, Tangzhiming Li, Qin Chen, Wen Zhang, Xinyi Zhou, Jiayao Ma, Boqing Liu, Zaixin Yu, Lihuang Zha, Mengqiu Zhang

TDAG8-mediated distinct signaling pathways modulate the early and late phases of neuropathic pain

Published: 13 September 2024 DOI: 10.1016/j.isci.2024.110955
Shih-Ping Dai , Chun-Chieh Yang , Yin Chin , Wei-Hsin Sun

Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors

Published: 31 August 2024 DOI: 10.1016/j.isci.2024.110862
Yuxiang Hu , Ziqi He , Shuangai Liu , Wenwen Ying , Yifan Chen , Manli Zhao , Min He , Xuan Wu , Yinbing Tang , Weizhong Gu , Meidan Ying , Jinhu Wang , Ting Tao

Targeting Parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis.

Published: 27 July 2024 DOI:
Yiyang Ma , Yidan Pang , Ruomu Cao , Zhikai Zheng , Kaiwen Zheng , Yucheng Tian , Xiaoyuan Peng , Delin Liu , Dajiang Du , Lin Du , Zhigang Zhong , Lufeng Yao , Changqing Zhang , Junjie Gao

A small molecule that selectively inhibits the growth of Epstein-Barr virus-latently infected cancer cells

Published: 25 July 2024 DOI: 10.1016/j.isci.2024.110581
Ying Li , Shujuan Du , Kun Zhou , Yulin Zhang , Xiaoting Chen , Caixia Zhu , Yuping Jia , Yuyan Wang , Daizhou Zhang , Fang Wei , Yin Tong , Qiliang Cai

AKAP8 promotes ovarian cancer progression and antagonizes PARP inhibitor sensitivity through regulating hnRNPUL1 transcription

Published: 16 April 2024 DOI:
Youchaou Mobet, Haocheng Wang, Qinglv Wei, Xiaoyi Liu, Dan Yang, Hongyan Zhao, Yu Yang, Rosalie Anne Ngono Ngane, Jacob Souopgui, Jing Xu, Tao Liu, Ping Yi

Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells

Published: 6 December 2023 DOI: 10.1016/j.isci.2023.108645
Zhe Cheng , Huichao Huang , Maoyu Li , Yongheng Chen

Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats.

Published: 3 November 2023 DOI: 10.1016/j.isci.2023.108392
Hanxiang Sun , Xiujuan Su , Yang Liu , Guohua Li , Qiaoling Du