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Science Advances

IF:11.7 CiteScore:21.4 Articles:1937

Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.

Cascade-targeting pH/ROS microneedles promote scarless diabetic wound healing by macrophage metaboimmune reprogramming

Published: 31 October 2025 DOI: 10.1126/sciadv.adw3834
Ganghua Yang, Jianqiu Yang, Zhaoping Diao, Jiajun Long, Zhiwen Shu, Chengkang Liu, Wenbing Wan

Pt-seq unveils the genomic binding pattern of platinum-based drugs

Published: 29 October 2025 DOI: 10.1126/sciadv.adx6809
Chuyun Shao, Mingyang Li, Liuyi Liu, Dongsheng Bai, Jinmin Yang, Cong Liu, Linxiang Cai, Xiaoyong Wang, Jinying Peng, Zijian Guo, Chengqi Yi

BRD4770 protects against DOX-induced cardiotoxicity by inhibiting apoptosis and ferroptosis

Published: 11 July 2025 DOI: 10.1126/sciadv.adw1720
Jingrong Shao, Rui Xiao, Ting Wang, Fengshuo Wang, Bei Wang, Dongli Zhang, Lulu Wang, Jingchao Li, Jiao Liu, Shengkai Zuo

The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5

Published: 18 June 2025 DOI: 10.1126/sciadv.adv2417
Man Zhao, Dalin Zhang, Haowen Jiang, Nishanth Kuganesan, Suchitra Natarajan, Leighton Pu, Kaushik N. Thakkar, Hongjuan Zhao, Quynh Thu Le, Amato J. Giaccia, James D. Brooks, Donna M. Peehl, Jiangbin Ye, Erinn B. Rankin

A rationally designed injury kidney targeting peptide library and its application in rescuing acute kidney injury

Published: 2 May 2025 DOI: 10.1126/sciadv.adt3943
Yushuo Xiao, Zhijian Tong, Huidie Xu, Zhouyan Jia, Chen Wang, Yang Cao, Liangliang Song, Siyu Hao, Jing Yang, Yihao Zhou, Yunhao Xie, Peng Wu, Tong He, Yancai Wu, Robert B. Petersen, Anlin Peng, Chun Zhang, Hong Chen, Ling Zheng, Kun Huang

Framework nucleic acid strategy enables closer microbial contact for programming short-range interaction

Published: 13 December 2024 DOI: 10.1126/sciadv.adr4399
Na Chen, Jing Xi, Na Du, Ruichen Shen, Rui Zhao, Wei He, Tianhuang Peng, Yanbing Yang, Yun Zhang, Lilei Yu, Weihong Tan, Quan Yuan

INSPIRE: Single-beam probed complementary vibrational bioimaging

Published: 13 December 2024 DOI: 10.1126/sciadv.adm7687
Pengcheng Fu, Yongqing Zhang, Siming Wang, Xin Ye, Yunhong Wu, Mengfei Yu, Shiyao Zhu, Hyeon Jeong Lee, Delong Zhang

Comediation of voltage gating and ion charge in MXene membrane for controllable and selective monovalent cation separation

Published: 6 December 2024 DOI: 10.1126/sciadv.ado3998
Xu Wang, Haiguang Zhang, Gaoliang Wei, Jiajian Xing, Shuo Chen, Xie Quan

Fish-inspired dynamic charging for ultrafast self-protective solar-thermal energy storage

Published: 6 December 2024 DOI: 10.1126/sciadv.adr8445
Xiaoxiang Li, Jingyi Zhang, Yizhe Liu, Yangzhe Xu, Yixuan Xie, Ting Hu, Benwei Fu, Chengyi Song, Wen Shang, Peng Tao, Tao Deng

In vivo dynamic tracking of cerebral chloride regulation using molecularly tailored liquid/liquid interfacial ultramicro iontronics

Published: 6 December 2024 DOI: 10.1126/sciadv.adr7218
Chaoyue Gu, Fanzhen Kong, Sen Liang, Xiang Zhao, Bingjie Kong, Tianhe Jiang, Jianan Yu, Qi Li, Yuqing Lin, Shuo Bai, Yuanhua Shao

Generation and characterization of giant panda induced pluripotent stem cells

Published: 20 September 2024 DOI: 10.1126/sciadv.adn7724
Yuliang Liu, Shihao Zhang, Gaoyang Zou, Junhui An, Yuan Li, Danni Lin, Donghui Wang, Yan Li, Jiasong Chen, Tongying Feng, Hongyan Li, Yijiao Chen, Mingyue Zhang, Manish Kumar, Luqin Wang, Rong Hou, Jing Liu

Essential and multifunctional mpox virus E5 helicase-primase in double and single hexamer

Published: 21 August 2024 DOI: 10.1126/sciadv.adl1150
Yunxia Xu, Yaqi Wu, Yuanyuan Zhang, Kaiting Gao, Xiaoying Wu, Yaxue Yang, Danyang Li, Biao Yang, Zhengyu Zhang, Changjiang Dong

Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release

Published: 17 May 2024 DOI: 10.1126/sciadv.adi7024
Hong Zhang, Mengshi Lei, Yu Zhang, Hao Li, Zhen He, Sheng Xie, Le Zhu, Shen Wang, Jianfeng Liu, Yan Li, Youming Lu, Cong Ma

Identification of an anaplastic subtype of prostate cancer amenable to therapies targeting SP1 or translation elongation

Published: 3 April 2024 DOI: 10.1126/sciadv.adm7098
Cheng Zou, Wenchao Li, Yuanzhen Zhang, Ninghan Feng, Saisai Chen, Lianlian Yan, Qinju He, Kai Wang, Wenjun Li, Yingying Li, Yang Wang, Bin Xu, Dingxiao Zhang

Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases

Published: 29 March 2024 DOI: 10.1126/sciadv.adk1200
Qian Huang, Yi Ru, Yingli Luo, Xianyu Luo, Didi Liu, Yinchu Ma, Xinru Zhou, Maoyuan Linghu, Wen Xu, Fei Gao, Yi Huang

Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity

Published: 28 February 2024 DOI:
Lu Chen, Zijun Qian, Yuyuan Zheng, Jie Zhang, Jie Sun, Chun Zhou, Haowen Xiao

Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs

Published: 9 February 2024 DOI: 10.1126/sciadv.adk5184
James Jiqi Wang, Sanshan Jin, Heng Zhang, Youwei Xu, Wen Hu, Yi Jiang, Chen Chen, Dao Wen Wang, H. Eric Xu, Canrong Wu

NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation

Published: 7 February 2024 DOI: 10.1126/sciadv.adi9284
Xueqin Jiang, Xinlu Zhang, Xiaoying Cai, Na Li, Hongyu Zheng, Minghai Tang, Jiangli Zhu, Kaiyue Su, Ruijia Zhang, Neng Ye, Jing Peng, Min Zhao, Wenshuang Wu, Jianhong Yang, Haoyu Ye

N-acetyltransferase NAT10 controls cell fates via connecting mRNA cytidine acetylation to chromatin signaling

Published: 12 January 2024 DOI: 10.1126/sciadv.adh9871
Zhensheng Hu, Yunkun Lu, Jie Cao, Lianyu Lin, Xi Chen, Ziyu Zhou, Jiaqi Pu, Guo Chen, Xiaojie Ma, Qian Deng, Yan Jin, Liling Jiang, Yuhan Li, Tengwei Li, Jianzhao Liu, Saiyong Zhu

Iron deficiency–induced ferritinophagy impairs skeletal muscle regeneration through RNF20-mediated H2Bub1 modification

Published: 17 November 2023 DOI:
Yunshu Che, Jinteng Li, Peng Wang, Wenhui Yu, Jiajie Lin, Zepeng Su, Feng Ye, Zhaoqiang Zhang, Peitao Xu, Zhongyu Xie, Yanfeng Wu, Huiyong Shen

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