Zhengzhou Yuanli Biological Technology Co., Ltd.

Zhengzhou Yuanli Biological Technology Co., Ltd.

Main products: Borane Series; Acridine Series; Intermediate

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Medical application of acridone acetate and lipids

Release time: 2019-01-03

According to the Russian scientist Sukov, Kirill Gennadievich's patent (WO/2008/121028, WO/2008/121029) studies, acridone acetate and lipids, through hormone therapy, can affect the male hormones in the human body, can be used for treatment And prevention of female reproductive system malignancies, such as breast cancer, uterine cancer, ovarian cancer; can also be used to treat male hair loss, prostate tumor, prostate cancer and prostate cancer recurrence.

Therefore, acridone acetic acid (water-soluble sodium acridinone acetate) has obtained the corresponding SDFS authorization in Russia and other countries, and the clinical effect is good, and the demand for acridone acetic acid is also increasing year by year. At present, medical research on acridone acetate and lipids has not been found in China.

A drug for treating and preventing malignant tumors of the female reproductive system using 9-oxoacridine-10-acetic acid and/or a salt thereof and/or an ester thereof.

The present invention relates to a female reproductive system in an organ for treating and/or preventing a tumor.

According to the invention, a method of combining treatments, the method comprising the steps of:

(A) administering an effective amount of 9-oxoacridine-10-acetic acid and/or a pharmaceutically acceptable salt and/or ester thereof to a patient in need thereof.
(B) Hormone therapy is directed to reducing aromatase activity. The proposed method is suitable for the treatment of cancers of breast, uterus and ovarian cancer.
The use of 9-oxoacridine-10-acetic acid, the salts and esters thereof, is used to enhance anti-androgen therapy.

The present invention provides the use of 9-oxoacridine-10-acetic acid, the pharmaceutically acceptable salts and esters thereof being advantageous in the treatment of therapeutic conditions to reduce androgenic effects.

In addition, reduced pharmaceutical compositions include androgenic effects

(A) 9-oxoacridine-10-acetic acid, a pharmaceutically acceptable salt or ester thereof,
The method of at least one antiandrogen and the reduction of androgenic effects for treating a condition are therapeutically beneficial, the method comprising the steps of:

(A) administering an effective amount of a compound selected from the group consisting of 9-oxoacridine-10-acetic acid, pharmaceutically acceptable salts and esters thereof, in patients in need of such treatment,
(B) Hormone therapy aims to reduce the effects of androgens. Such conditions include, but are not limited to, increased risk of recurrence of alopecia, prostate adenoma, prostate cancer, and prostate cancer.