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Nitrogen-containing heterocyclic organic compound - acridine

Release time: 2019-01-03

As an important heterocyclic organic compound, acridine has attracted great attention due to its novel heterocyclic chemistry, wide range of properties and its application.

Nitrogen-containing heterocyclic organic compound - acridine
Nitrogen-containing heterocyclic organic compounds have very important commercial value and can be used as chemical intermediates, fine chemicals, and pharmaceutical intermediates, and they can play an important role in scientific research, chemical industry, and medicine.

As an important heterocyclic organic compound, acridine has attracted great attention due to its novel heterocyclic chemistry, wide range of properties and its application.

Acridine derivatives have multifunctional biological activities such as antibacterial, antimalarial, anticancer and the like. Many chemists and pharmacists have invested a lot of energy in the research and development of such compounds and synthesized a series of new acridine compounds for their antibacterial, anti-inflammatory, analgesic, deworming, anti-schistosomiasis, memory enhancement and other properties. The research done by the parties has made great progress.

Some acridine derivatives have very good therapeutic effects in the treatment of cancer and tumors, and the application of acridine derivatives in medicine has become a boom in recent years.

The synthesis of most known acridine derivatives requires harsh reaction conditions such as high temperatures, strong alkaline or acidic media, or difficulty in obtaining the starting materials. Therefore, it is highly desirable to develop a new relatively mild synthetic method for the preparation of acridine derivatives.

Acridine derivatives are a class of nitrogen-containing organic heterocyclic compounds that have received extensive attention due to their superior bioactivity in anti-inflammatory, antibacterial and anti-tumor properties.

In recent years, the research results of acridine compounds in anti-tumor have been reviewed, and their main targets such as telomerase, topoisomerase I/II, tubulin, ABCG2/P-glycoprotein (P- gP) and protein kinase research. Acridine is a very useful small ring heterocyclic compound, widely used in the synthesis of many drugs and biologically active compounds.